Measurement of pH values in human tissues by two-photon microscopy

Hee Jung Park; Chang Su Lim; Eun Sun Kim; Ji Hee Han; Tae Hee Lee; Hoon Jai Chun; Bong Rae Cho

doi:10.1002/anie.201109052

Measurement of pH values in human tissues by two-photon microscopy

Hee Jung Park, Chang Su Lim, Eun Sun Kim, Ji Hee Han, Tae Hee Lee, Hoon Jai Chun, Bong Rae Cho

* Honorary professors

Research output: Contribution to journal › Article › peer-review

76 Citations (Scopus)

Abstract

pH values go live! A ratiometric two-photon (TP) probe (NP1, see scheme) that has a significant TP action cross-section, high photostability, negligible toxicity, and can estimate pH values in live cells and human tissues by two-photon microscopy is described. NP1 can detect the difference in pH between live cells from the gastroesophageal junction (GEJ) and the lower esophageal sphincter of patients with and without esophagitis (see image).

Original language	English
Pages (from-to)	2673-2676
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	11
DOIs	https://doi.org/10.1002/anie.201109052
Publication status	Published - 2012 Mar 12

Keywords

fluorescent probes
imaging agents
live-cell imaging
naphthalenes
two-photon microscopy

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.201109052

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AU - Kim, Eun Sun

AU - Han, Ji Hee

AU - Lee, Tae Hee

AU - Chun, Hoon Jai

AU - Cho, Bong Rae

PY - 2012/3/12

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AB - pH values go live! A ratiometric two-photon (TP) probe (NP1, see scheme) that has a significant TP action cross-section, high photostability, negligible toxicity, and can estimate pH values in live cells and human tissues by two-photon microscopy is described. NP1 can detect the difference in pH between live cells from the gastroesophageal junction (GEJ) and the lower esophageal sphincter of patients with and without esophagitis (see image).

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KW - imaging agents

KW - live-cell imaging

KW - naphthalenes

KW - two-photon microscopy

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Measurement of pH values in human tissues by two-photon microscopy

Abstract

Keywords

ASJC Scopus subject areas

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