Measurement of pH values in human tissues by two-photon microscopy

Hee Jung Park, Chang Su Lim, Eun Sun Kim, Ji Hee Han, Tae Hee Lee, Hoon Jai Chun, Bong Rae Cho

Research output: Contribution to journalArticlepeer-review

76 Citations (Scopus)


pH values go live! A ratiometric two-photon (TP) probe (NP1, see scheme) that has a significant TP action cross-section, high photostability, negligible toxicity, and can estimate pH values in live cells and human tissues by two-photon microscopy is described. NP1 can detect the difference in pH between live cells from the gastroesophageal junction (GEJ) and the lower esophageal sphincter of patients with and without esophagitis (see image).

Original languageEnglish
Pages (from-to)2673-2676
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number11
Publication statusPublished - 2012 Mar 12


  • fluorescent probes
  • imaging agents
  • live-cell imaging
  • naphthalenes
  • two-photon microscopy

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


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