Measurement of the temperature-dependent threshold shear-stress of red blood cell aggregation

Hyun Jung Lim, Jeong Hun Nam, Yong Jin Lee, Sehyun Shin

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2 Citations (Scopus)


Red blood cell (RBC) aggregation is becoming an important hemorheological parameter, which typically exhibits temperature dependence. Quite recently, a critical shear-stress was proposed as a new dimensional index to represent the aggregative and disaggregative behaviors of RBCs. The present study investigated the effect of the temperature on the critical shear-stress that is required to keep RBC aggregates dispersed. The critical shear-stress was measured at various temperatures (4, 10, 20, 30, and 37 °C) through the use of a transient microfluidic aggregometry. The critical shear-stress significantly increased as the blood temperature lowered, which accorded with the increase in the low-shear blood viscosity with the lowering of the temperature. Furthermore, the critical shear-stress also showed good agreement with the threshold shear-stress, as measured in a rotational Couette flow. These findings assist in rheologically validating the critical shear-stress, as defined in the microfluidic aggregometry.

Original languageEnglish
Article number096101
JournalReview of Scientific Instruments
Issue number9
Publication statusPublished - 2009

Bibliographical note

Funding Information:
This research was supported by the Seoul R&BD Program (Grant No. NT080573).

ASJC Scopus subject areas

  • Instrumentation


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