Measuring longitudinally dynamic cortex development in infants by reconstruction of consistent cortical surfaces

Gang Li, Jingxin Nie, Li Wang, Feng Shi, John H. Gilmore, Weili Lin, Dinggang Shen

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    3 Citations (Scopus)

    Abstract

    Quantitative measurement of dynamic cortex development during early postnatal stages is of great importance to understand early cortical structural and functional development. Conventional methods usually independently reconstruct cortical surfaces of longitudinal images from the same infant, which often generates longitudinally-inconsistent cortical surfaces and leads to inconsistence in cortex development measurement. This paper aims to address this problem by presenting a method to reconstruct consistent cortical surfaces from longitudinal brain MR images in the first-year infants for accurate and consistent measurement of dynamic cortex development. Specifically, longitudinal development of the inner cortical surface is first modeled by a deformable sheet with elasto-plasticity property to establish longitudinally smooth correspondences of inner cortical surfaces. Then, the modeled longitudinal inner cortical surfaces are jointly deformed to locate inner and outer cortical surfaces with a spatial-temporal deformable surface. The method has been applied on 10 infants, each with 5 or 6 scans acquired at every 3 months from birth. Experimental results show that our method can accurately and consistently reconstruct dynamic cortical surfaces from longitudinal infant images, with the average surface distance as low as 0.2mm. By using our method, we can quantitatively characterize longitudinally dynamic cortical thickness development in the first-year infants.

    Original languageEnglish
    Title of host publicationISBI 2013 - 2013 IEEE 10th International Symposium on Biomedical Imaging
    Subtitle of host publicationFrom Nano to Macro
    Pages1380-1383
    Number of pages4
    DOIs
    Publication statusPublished - 2013
    Event2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2013 - San Francisco, CA, United States
    Duration: 2013 Apr 72013 Apr 11

    Publication series

    NameProceedings - International Symposium on Biomedical Imaging
    ISSN (Print)1945-7928
    ISSN (Electronic)1945-8452

    Other

    Other2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2013
    Country/TerritoryUnited States
    CitySan Francisco, CA
    Period13/4/713/4/11

    Keywords

    • infant cortical thickness development
    • infant longitudinal cortical surfaces

    ASJC Scopus subject areas

    • Biomedical Engineering
    • Radiology Nuclear Medicine and imaging

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