Mechanical and cold allodynia in a rat spinal cord contusion model

Young Wook Yoon; Hongxin Dong; Joop J.A. Arends; Mark F. Jacquin

doi:10.1080/0899022042000201272

Mechanical and cold allodynia in a rat spinal cord contusion model

Young Wook Yoon, Hongxin Dong, Joop J.A. Arends, Mark F. Jacquin

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

This study examined the time course of mechanical and cold allodynia in rat hindpaw after spinal cord contusion. Hindpaw withdrawal threshold to graded von Frey hair stimulation and withdrawal frequency to acetone application were measured in rats subjected to contusions of varying severity, produced by a MASCIS impactor device with a 10 g weight dropped from 6.25, 12.5, or 25 mm. Mechanical and cold allodynia developed following the injury, and differences in the incidence of allodynia and in withdrawal threshold were significant among these groups. The least severe injury (6.25 mm) most consistently caused a decreased hindpaw threshold to mechanical stimulation and an increased withdrawal frequency to cold.

Original language	English
Pages (from-to)	25-31
Number of pages	7
Journal	Somatosensory and Motor Research
Volume	21
Issue number	1
DOIs	https://doi.org/10.1080/0899022042000201272
Publication status	Published - 2004

Bibliographical note

Funding Information:
The authors would like to thank Dr Michael Howard for his comments on the manuscript. This work was supported by NIH grant NS39577 to M.F.J. Y.W. Yoon was supported in part by the Kil Chung Hee Fellowship Fund.

Keywords

Allodynia
Hindpaw
Injury
Neuropathic pain
Spinal cord
Von Frey

ASJC Scopus subject areas

Physiology
Sensory Systems

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10.1080/0899022042000201272

Cite this

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abstract = "This study examined the time course of mechanical and cold allodynia in rat hindpaw after spinal cord contusion. Hindpaw withdrawal threshold to graded von Frey hair stimulation and withdrawal frequency to acetone application were measured in rats subjected to contusions of varying severity, produced by a MASCIS impactor device with a 10 g weight dropped from 6.25, 12.5, or 25 mm. Mechanical and cold allodynia developed following the injury, and differences in the incidence of allodynia and in withdrawal threshold were significant among these groups. The least severe injury (6.25 mm) most consistently caused a decreased hindpaw threshold to mechanical stimulation and an increased withdrawal frequency to cold.",

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Mechanical and cold allodynia in a rat spinal cord contusion model

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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