Mechanical characterization of amyloid fibrils using coarse-grained normal mode analysis

Gwonchan Yoon, Jinhak Kwak, Jae In Kim, Sungsoo Na, Kilho Eom

    Research output: Contribution to journalArticlepeer-review

    55 Citations (Scopus)

    Abstract

    Recent experimental studies have shown that amyloid fibril formed by aggregation of β peptide exhibits excellent mechanical properties comparable to other protein materials such as actin filaments and microtubules. These excellent mechanical properties of amyloid fibrils are related to their functional role in disease expression. This indicates the necessity of understanding how an amyloid fibril achieves the remarkable mechanical properties through self-aggregation with structural hierarchy. However, the structure-property-function relationship still remains elusive. In this work, the mechanical properties of human islet amyloid polypeptide (hIAPP) are studied with respect to its structural hierarchies and structural shapes by coarse-grained normal mode analysis. The simulation shows that hIAPP fibril can achieve the excellent bending rigidity via specific aggregation patterns such as antiparallel stacking of β peptides. Moreover, the length-dependent mechanical properties of amyloids are found. This length-dependent property has been elucidated from a Timoshenko beam model that takes into account the shear effect on the bending of amyloids. In summary, the study sheds light on the importance of not only the molecular architecture, which encodes the mechanical properties of the fibril, but also the shear effect on the mechanical (bending) behavior of the fibril.

    Original languageEnglish
    Pages (from-to)3454-3463
    Number of pages10
    JournalAdvanced Functional Materials
    Volume21
    Issue number18
    DOIs
    Publication statusPublished - 2011 Sept 23

    Keywords

    • Amyloid fibrils
    • Normal Mode Analysis
    • mechanical testing

    ASJC Scopus subject areas

    • General Chemistry
    • General Materials Science
    • Condensed Matter Physics

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