Mechanics of the cell nucleus

Dong Hwee Kim, Jungwon Hah, Denis Wirtz

Research output: Chapter in Book/Report/Conference proceedingChapter

15 Citations (Scopus)

Abstract

Nucleus is a specialized organelle that serves as a control tower of all the cell behavior. While traditional biochemical features of nuclear signaling have been unveiled, many of the physical aspects of nuclear system are still under question. Innovative biophysical studies have recently identified mechano-regulation pathways that turn out to be critical in cell migration, particularly in cancer invasion and metastasis. Moreover, to take a deeper look onto the oncologic relevance of the nucleus, there has been a shift in cell systems. That is, our understanding of nucleus does not stand alone but it is understood by the relationship between cell and its microenvironment in the in vivo-relevant 3D space.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages41-55
Number of pages15
DOIs
Publication statusPublished - 2018

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1092
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Bibliographical note

Funding Information:
Authors are indebted to many colleagues and students for their input and perspectives of nuclear mechanics. Special thanks to Dr. Denis Wirtz at the Johns Hopkins University, who provided overall guidance of this chapter. We appreciated Geonhui Lee, Seong-Beom Han, Jung-Won Park, and Jeong-Ki Kim in the Applied Mechanobiology Group (AMG) at Korea University for in-depth discussion of cellular and nuclear mechanobiology. This work was supported by the KU-KIST Graduate School of Converging Science and Technology Program, the National Research Foundation of Korea (NRF-2016R1C1B2015018 and NRF-2017K2A9A1A01092963), and Korea University Future Research Grant.

Publisher Copyright:
© Springer Nature Switzerland AG 2018.

Keywords

  • Mechanotransduction
  • Nuclear envelope
  • Nuclear lamina
  • Nuclear mechanics
  • Nucleoskeleton

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology

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