Mechanism of Bisphenol F Affecting Motor System and Motor Activity in Zebrafish

Yeonhwa Kim; Seong Soon Kim; Byeong Heon Park; Kyu Seok Hwang; Myung Ae Bae; Sung Hee Cho; Suhyun Kim; Hae Chul Park

doi:10.3390/toxics11060477

Mechanism of Bisphenol F Affecting Motor System and Motor Activity in Zebrafish

Yeonhwa Kim, Seong Soon Kim, Byeong Heon Park, Kyu Seok Hwang, Myung Ae Bae, Sung Hee Cho, Suhyun Kim, Hae Chul Park

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Bisphenol F (BPF; 4,4′-dihydroxydiphenylmethane) is one of the most frequently used compounds in the manufacture of plastics and epoxy resins. Previous studies have demonstrated that BPF affects locomotor behavior, oxidative stress, and neurodevelopment in zebrafish. However, its neurotoxic effects are controversial, and the underlying mechanisms are unclear. In order to determine whether BPF affects the motor system, we exposed zebrafish embryos to BPF and assessed behavioral, histological, and neurochemical changes. Spontaneous locomotor behavior and startle response were significantly decreased in BPF-treated zebrafish larvae compared with control larvae. BPF induced motor degeneration and myelination defects in zebrafish larvae. In addition, embryonic exposure to BPF resulted in altered metabolic profiles of neurochemicals, including neurotransmitters and neurosteroids, which may impact locomotion and motor function. In conclusion, exposure to BPF has the potential to affect survival, motor axon length, locomotor activity, myelination, and neurochemical levels of zebrafish larvae.

Original language	English
Article number	477
Journal	Toxics
Volume	11
Issue number	6
DOIs	https://doi.org/10.3390/toxics11060477
Publication status	Published - 2023 Jun

Bibliographical note

Funding Information:
This research was supported by the Korea Environment Industry and Technology Institute (KEITI) through the Technology Development Project for Safety Management of Household Chemical Products, funded by the Korean Ministry of Environment (MOE) (2020002960007, NTIS-1485017544).

Publisher Copyright:
© 2023 by the authors.

Keywords

bisphenol F
locomotion
motor neuron
myelination
neurochemicals
zebrafish

ASJC Scopus subject areas

Toxicology
Health, Toxicology and Mutagenesis
Chemical Health and Safety

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10.3390/toxics11060477

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title = "Mechanism of Bisphenol F Affecting Motor System and Motor Activity in Zebrafish",

abstract = "Bisphenol F (BPF; 4,4′-dihydroxydiphenylmethane) is one of the most frequently used compounds in the manufacture of plastics and epoxy resins. Previous studies have demonstrated that BPF affects locomotor behavior, oxidative stress, and neurodevelopment in zebrafish. However, its neurotoxic effects are controversial, and the underlying mechanisms are unclear. In order to determine whether BPF affects the motor system, we exposed zebrafish embryos to BPF and assessed behavioral, histological, and neurochemical changes. Spontaneous locomotor behavior and startle response were significantly decreased in BPF-treated zebrafish larvae compared with control larvae. BPF induced motor degeneration and myelination defects in zebrafish larvae. In addition, embryonic exposure to BPF resulted in altered metabolic profiles of neurochemicals, including neurotransmitters and neurosteroids, which may impact locomotion and motor function. In conclusion, exposure to BPF has the potential to affect survival, motor axon length, locomotor activity, myelination, and neurochemical levels of zebrafish larvae.",

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author = "Yeonhwa Kim and Kim, {Seong Soon} and Park, {Byeong Heon} and Hwang, {Kyu Seok} and Bae, {Myung Ae} and Cho, {Sung Hee} and Suhyun Kim and Park, {Hae Chul}",

note = "Funding Information: This research was supported by the Korea Environment Industry and Technology Institute (KEITI) through the Technology Development Project for Safety Management of Household Chemical Products, funded by the Korean Ministry of Environment (MOE) (2020002960007, NTIS-1485017544). Publisher Copyright: {\textcopyright} 2023 by the authors.",

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doi = "10.3390/toxics11060477",

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journal = "Toxics",

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AU - Kim, Yeonhwa

AU - Kim, Seong Soon

AU - Park, Byeong Heon

AU - Hwang, Kyu Seok

AU - Bae, Myung Ae

AU - Cho, Sung Hee

AU - Kim, Suhyun

AU - Park, Hae Chul

N1 - Funding Information: This research was supported by the Korea Environment Industry and Technology Institute (KEITI) through the Technology Development Project for Safety Management of Household Chemical Products, funded by the Korean Ministry of Environment (MOE) (2020002960007, NTIS-1485017544). Publisher Copyright: © 2023 by the authors.

PY - 2023/6

Y1 - 2023/6

N2 - Bisphenol F (BPF; 4,4′-dihydroxydiphenylmethane) is one of the most frequently used compounds in the manufacture of plastics and epoxy resins. Previous studies have demonstrated that BPF affects locomotor behavior, oxidative stress, and neurodevelopment in zebrafish. However, its neurotoxic effects are controversial, and the underlying mechanisms are unclear. In order to determine whether BPF affects the motor system, we exposed zebrafish embryos to BPF and assessed behavioral, histological, and neurochemical changes. Spontaneous locomotor behavior and startle response were significantly decreased in BPF-treated zebrafish larvae compared with control larvae. BPF induced motor degeneration and myelination defects in zebrafish larvae. In addition, embryonic exposure to BPF resulted in altered metabolic profiles of neurochemicals, including neurotransmitters and neurosteroids, which may impact locomotion and motor function. In conclusion, exposure to BPF has the potential to affect survival, motor axon length, locomotor activity, myelination, and neurochemical levels of zebrafish larvae.

AB - Bisphenol F (BPF; 4,4′-dihydroxydiphenylmethane) is one of the most frequently used compounds in the manufacture of plastics and epoxy resins. Previous studies have demonstrated that BPF affects locomotor behavior, oxidative stress, and neurodevelopment in zebrafish. However, its neurotoxic effects are controversial, and the underlying mechanisms are unclear. In order to determine whether BPF affects the motor system, we exposed zebrafish embryos to BPF and assessed behavioral, histological, and neurochemical changes. Spontaneous locomotor behavior and startle response were significantly decreased in BPF-treated zebrafish larvae compared with control larvae. BPF induced motor degeneration and myelination defects in zebrafish larvae. In addition, embryonic exposure to BPF resulted in altered metabolic profiles of neurochemicals, including neurotransmitters and neurosteroids, which may impact locomotion and motor function. In conclusion, exposure to BPF has the potential to affect survival, motor axon length, locomotor activity, myelination, and neurochemical levels of zebrafish larvae.

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Mechanism of Bisphenol F Affecting Motor System and Motor Activity in Zebrafish

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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