Mechanisms of patulin toxicity under conditions that inhibit yeast growth

Yumiko Iwahashi, Hiroshi Hosoda, Ji Hyun Park, Joo Hee Lee, Yoshiteru Suzuki, Emiko Kitagawa, Satomi Mizukami Murata, Nam Soo Jwa, Man Bock Gu, Hitoshi Iwahashi

Research output: Contribution to journalArticlepeer-review

71 Citations (Scopus)


Patulin, 4-hydroxy-4H-furo[3,2c]pyran-2(6H)-one, is one of the best characterized and most widely disseminated mycotoxins found in agricultural products. Nonetheless, the mechanisms by which patulin causes toxicity are not well understood. Thus, the cytotoxicity of patulin was characterized by analysis of the yeast transcriptome upon challenge with patulin. Interestingly, patulin-induced yeast gene expression profiles were found to be similar to gene expression patterns obtained after treatment with the antifungal agricultural chemicals thiuram, maneb, and zineb. Moreover, patulin treatment was found to activate protein degradation, especially proteasome activities, sulfur amino acid metabolism, and the defense system for oxidative stress. Damage to DNA by alkylation was also suggested, and this seemed to be repaired by recombinational and excision repair mechanisms. Furthermore, the results provide potential biomarker genes for the detection of patulin in agricultural products. The results suggest the possibility of applying the yeast transcriptome system for the evaluation of chemicals, especially for natural chemicals that are difficult to get by organic synthesis.

Original languageEnglish
Pages (from-to)1936-1942
Number of pages7
JournalJournal of agricultural and food chemistry
Issue number5
Publication statusPublished - 2006 Mar 8


  • DNA microarry
  • Mutagenesis
  • Mycotoxin
  • Patulin
  • Yeast

ASJC Scopus subject areas

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)


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