Mechanistic mammalian target of rapamycin (MTOR) cell signaling: Effects of select nutrients and secreted phosphoprotein 1 on development of mammalian conceptuses

Fuller W. Bazer; Gwonhwa Song; Jinyoung Kim; David W. Erikson; Greg A. Johnson; Robert C. Burghardt; Haijun Gao; M. Carey Satterfield; Thomas E. Spencer; Guoyao Wu

doi:10.1016/j.mce.2011.08.026

Mechanistic mammalian target of rapamycin (MTOR) cell signaling: Effects of select nutrients and secreted phosphoprotein 1 on development of mammalian conceptuses

Fuller W. Bazer, Gwonhwa Song, Jinyoung Kim, David W. Erikson, Greg A. Johnson, Robert C. Burghardt, Haijun Gao, M. Carey Satterfield, Thomas E. Spencer, Guoyao Wu

Research output: Contribution to journal › Review article › peer-review

51 Citations (Scopus)

Abstract

Morphological differentiation of uterine glands in mammals is a postnatal event vulnerable to adverse effects of endocrine disruptors. Exposure of ewe lambs to a progestin from birth to postnatal day 56 prevents development of uterine glands and, as adults, the ewes are unable to exhibit estrous cycles or maintain pregnancy. Uterine epithelia secrete proteins and transport nutrients into the uterine lumen necessary for conceptus development, pregnancy recognition signaling and implantation, including arginine and secreted phosphoprotein 1 (SPP1). Arginine can be metabolized to nitric oxide and to polyamines or act directly to activate MTOR cell signaling to stimulate proliferation, migration, and mRNA translation in trophectoderm cells. SPP1 binds αvβ3 and α5β1 integrins and induces focal adhesion assembly, adhesion and migration of conceptus trophectoderm cells during implantation. Thus, arginine and SPP1 mediate growth, migration, cytoskeletal remodeling and adhesion of trophectoderm essential for pregnancy recognition signaling and implantation.

Original language	English
Pages (from-to)	22-33
Number of pages	12
Journal	Molecular and Cellular Endocrinology
Volume	354
Issue number	1-2
DOIs	https://doi.org/10.1016/j.mce.2011.08.026
Publication status	Published - 2012 May 6
Externally published	Yes

Bibliographical note

Funding Information:
Supported by USDA CSREES National Research Initiative Grant 2006-35203-17283, National Research Initiative Competitive Grant No. 2006-35203-17283 from the USDA National Institute of Food and Agriculture , and the World Class University (WCU) program (R31–10056) through the National Research Foundation of Korea funded by the Ministry of Education, Science, and Technology .

Keywords

Amino acids
Conceptus
Endocrine disruptor
Glucose
MTOR
Pregnancy
Secreted phosphoprotein 1
Uterus

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Endocrinology

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10.1016/j.mce.2011.08.026

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Bazer, F. W., Song, G., Kim, J., Erikson, D. W., Johnson, G. A., Burghardt, R. C., Gao, H., Carey Satterfield, M., Spencer, T. E., & Wu, G. (2012). Mechanistic mammalian target of rapamycin (MTOR) cell signaling: Effects of select nutrients and secreted phosphoprotein 1 on development of mammalian conceptuses. Molecular and Cellular Endocrinology, 354(1-2), 22-33. https://doi.org/10.1016/j.mce.2011.08.026

Mechanistic mammalian target of rapamycin (MTOR) cell signaling: Effects of select nutrients and secreted phosphoprotein 1 on development of mammalian conceptuses. / Bazer, Fuller W.; Song, Gwonhwa; Kim, Jinyoung et al.
In: Molecular and Cellular Endocrinology, Vol. 354, No. 1-2, 06.05.2012, p. 22-33.

Research output: Contribution to journal › Review article › peer-review

Bazer, FW, Song, G, Kim, J, Erikson, DW, Johnson, GA, Burghardt, RC, Gao, H, Carey Satterfield, M, Spencer, TE & Wu, G 2012, 'Mechanistic mammalian target of rapamycin (MTOR) cell signaling: Effects of select nutrients and secreted phosphoprotein 1 on development of mammalian conceptuses', Molecular and Cellular Endocrinology, vol. 354, no. 1-2, pp. 22-33. https://doi.org/10.1016/j.mce.2011.08.026

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abstract = "Morphological differentiation of uterine glands in mammals is a postnatal event vulnerable to adverse effects of endocrine disruptors. Exposure of ewe lambs to a progestin from birth to postnatal day 56 prevents development of uterine glands and, as adults, the ewes are unable to exhibit estrous cycles or maintain pregnancy. Uterine epithelia secrete proteins and transport nutrients into the uterine lumen necessary for conceptus development, pregnancy recognition signaling and implantation, including arginine and secreted phosphoprotein 1 (SPP1). Arginine can be metabolized to nitric oxide and to polyamines or act directly to activate MTOR cell signaling to stimulate proliferation, migration, and mRNA translation in trophectoderm cells. SPP1 binds αvβ3 and α5β1 integrins and induces focal adhesion assembly, adhesion and migration of conceptus trophectoderm cells during implantation. Thus, arginine and SPP1 mediate growth, migration, cytoskeletal remodeling and adhesion of trophectoderm essential for pregnancy recognition signaling and implantation.",

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Mechanistic mammalian target of rapamycin (MTOR) cell signaling: Effects of select nutrients and secreted phosphoprotein 1 on development of mammalian conceptuses

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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