Medication event monitoring system for infectious tuberculosis treatment in Morocco: A retrospective cohort study

Seup Park; Ilham Sentissi; Seung Jae Gil; Won Seok Park; Byung Kwon Oh; Ah Reum Son; Young Ju Kong; Sol Park; Eunseong Paek; Yong Joon Park; Seung Heon Lee

doi:10.3390/ijerph16030412

Medication event monitoring system for infectious tuberculosis treatment in Morocco: A retrospective cohort study

Seup Park, Ilham Sentissi, Seung Jae Gil, Won Seok Park, Byung Kwon Oh, Ah Reum Son, Young Ju Kong, Sol Park, Eunseong Paek, Yong Joon Park, Seung Heon Lee

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Non-adherence to tuberculosis (TB) treatment is a barrier to effective TB control. We investigated the effectiveness of a Medication Event Monitoring System (MEMS) as a tailored adherence-promoting intervention in Morocco. We compared patients who received a MEMS (n = 206) with patients who received standard TB care (n = 141) among new active TB patients with sputum smear-positive. The mean total medication days were 141.87 ± 29.5 in the control group and 140.85 ± 17.9 in the MEMS group (p = 0.7147), and the mean age and sex were not different between the two groups (p > 0.05). The treatment success rate was significantly higher in the MEMS group than in the control group (odds ratio (OR): 4.33, 95% confidence interval (CI): 2.13-8.81, p < 0.001), and the lost to follow-up rate was significantly lower in the MEMS group than in the control group (OR: 0.03, 95% CI: 0.05-0.24, p < 0.001) after adjusting for sex, age, and health centers. The mean drug adherence rate in the first month was significantly higher in the MEMS group than in the control group (p = 0.023). MEMS increased TB treatment success rate and decreased the lost to follow-up rate overall for infectious TB patients in a Moroccan rural area.

Original language	English
Article number	412
Journal	International journal of environmental research and public health
Volume	16
Issue number	3
DOIs	https://doi.org/10.3390/ijerph16030412
Publication status	Published - 2019 Jan 1

Bibliographical note

Funding Information:
Funding: This research was supported by Korea International Cooperation Agency (KOICA) fund (2014-0027/ 2018-031).

Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Lost to follow-up rate
Medication event monitoring system
Morocco
Success rate
Tuberculosis

ASJC Scopus subject areas

Pollution
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/ijerph16030412

Cite this

Park, S., Sentissi, I., Gil, S. J., Park, W. S., Oh, B. K., Son, A. R., Kong, Y. J., Park, S., Paek, E., Park, Y. J., & Lee, S. H. (2019). Medication event monitoring system for infectious tuberculosis treatment in Morocco: A retrospective cohort study. International journal of environmental research and public health, 16(3), Article 412. https://doi.org/10.3390/ijerph16030412

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title = "Medication event monitoring system for infectious tuberculosis treatment in Morocco: A retrospective cohort study",

abstract = "Non-adherence to tuberculosis (TB) treatment is a barrier to effective TB control. We investigated the effectiveness of a Medication Event Monitoring System (MEMS) as a tailored adherence-promoting intervention in Morocco. We compared patients who received a MEMS (n = 206) with patients who received standard TB care (n = 141) among new active TB patients with sputum smear-positive. The mean total medication days were 141.87 ± 29.5 in the control group and 140.85 ± 17.9 in the MEMS group (p = 0.7147), and the mean age and sex were not different between the two groups (p > 0.05). The treatment success rate was significantly higher in the MEMS group than in the control group (odds ratio (OR): 4.33, 95% confidence interval (CI): 2.13-8.81, p < 0.001), and the lost to follow-up rate was significantly lower in the MEMS group than in the control group (OR: 0.03, 95% CI: 0.05-0.24, p < 0.001) after adjusting for sex, age, and health centers. The mean drug adherence rate in the first month was significantly higher in the MEMS group than in the control group (p = 0.023). MEMS increased TB treatment success rate and decreased the lost to follow-up rate overall for infectious TB patients in a Moroccan rural area.",

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author = "Seup Park and Ilham Sentissi and Gil, {Seung Jae} and Park, {Won Seok} and Oh, {Byung Kwon} and Son, {Ah Reum} and Kong, {Young Ju} and Sol Park and Eunseong Paek and Park, {Yong Joon} and Lee, {Seung Heon}",

note = "Funding Information: Funding: This research was supported by Korea International Cooperation Agency (KOICA) fund (2014-0027/ 2018-031). Publisher Copyright: {\textcopyright} 2019 by the authors. Licensee MDPI, Basel, Switzerland.",

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AU - Gil, Seung Jae

AU - Park, Won Seok

AU - Oh, Byung Kwon

AU - Son, Ah Reum

AU - Kong, Young Ju

AU - Park, Sol

AU - Paek, Eunseong

AU - Park, Yong Joon

AU - Lee, Seung Heon

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ER -

Medication event monitoring system for infectious tuberculosis treatment in Morocco: A retrospective cohort study

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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Cite this