Melampolides from the leaves of Smallanthus sonchifolius and their inhibitory activity of LPS-induced nitric oxide production

Seong Su Hong; Seon A. Lee; Xiang Hua Han; Min Hee Lee; Ji Sang Hwang; Jeong Sook Park; Ki Wan Oh; Kun Han; Myung Koo Lee; Heesoon Lee; Wook Kim; Dongho Lee; Bang Yeon Hwang

doi:10.1248/cpb.56.199

Melampolides from the leaves of Smallanthus sonchifolius and their inhibitory activity of LPS-induced nitric oxide production

Seong Su Hong, Seon A. Lee, Xiang Hua Han, Min Hee Lee, Ji Sang Hwang, Jeong Sook Park, Ki Wan Oh, Kun Han, Myung Koo Lee, Heesoon Lee, Wook Kim, Dongho Lee, Bang Yeon Hwang

Department of Biosystems and Biotechnology

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Two new melampolide-type sesquiterpene lactones, 8β-epoxyangeloyloxy- 9α-ethoxy-14-oxo-acanthospermolide (1) and 8β-angeloyloxy-9α- ethoxy-14-oxo-acanthospermolide (2), were isolated from the leaves of yacon [Smallanthus sonchifolia (POEPP. et ENDL.) H. Robinson] along with eleven known melampolides, allo-schkuhriolide (3), enhydrin (4), polymatin A (5), fluctuanin (6), 8β-angeloyloxy-9α-acetoxy-14-oxo-acanthospermolide (7), 8β-angeloyloxy-14-oxo-acanthospermolide (8), 8β- methacryloyloxymelampolid-14-oic acid methyl ester (9), uvedalin (10), polymatin B (11), 8β-tigloyloxymelampolid-14-oic acid methyl ester (12), and sonchifolin (13). Their structures were established on the basis of spectroscopic evidence including 1D- and 2D-NMR experiments. All isolates were evaluated for inhibition of LPS-induced nitric oxide production in murine macrophage RAW 264.7 cells.

Original language	English
Pages (from-to)	199-202
Number of pages	4
Journal	Chemical and Pharmaceutical Bulletin
Volume	56
Issue number	2
DOIs	https://doi.org/10.1248/cpb.56.199
Publication status	Published - 2008 Feb

Keywords

Asteraceae
Melampolide
Nitric oxide production inhibitor
Sesquiterpene lactone
Smallanthus sonchifolius
Yacon

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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10.1248/cpb.56.199

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Hong, S. S., Lee, S. A., Han, X. H., Lee, M. H., Hwang, J. S., Park, J. S., Oh, K. W., Han, K., Lee, M. K., Lee, H., Kim, W., Lee, D., & Hwang, B. Y. (2008). Melampolides from the leaves of Smallanthus sonchifolius and their inhibitory activity of LPS-induced nitric oxide production. Chemical and Pharmaceutical Bulletin, 56(2), 199-202. https://doi.org/10.1248/cpb.56.199

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abstract = "Two new melampolide-type sesquiterpene lactones, 8β-epoxyangeloyloxy- 9α-ethoxy-14-oxo-acanthospermolide (1) and 8β-angeloyloxy-9α- ethoxy-14-oxo-acanthospermolide (2), were isolated from the leaves of yacon [Smallanthus sonchifolia (POEPP. et ENDL.) H. Robinson] along with eleven known melampolides, allo-schkuhriolide (3), enhydrin (4), polymatin A (5), fluctuanin (6), 8β-angeloyloxy-9α-acetoxy-14-oxo-acanthospermolide (7), 8β-angeloyloxy-14-oxo-acanthospermolide (8), 8β- methacryloyloxymelampolid-14-oic acid methyl ester (9), uvedalin (10), polymatin B (11), 8β-tigloyloxymelampolid-14-oic acid methyl ester (12), and sonchifolin (13). Their structures were established on the basis of spectroscopic evidence including 1D- and 2D-NMR experiments. All isolates were evaluated for inhibition of LPS-induced nitric oxide production in murine macrophage RAW 264.7 cells.",

keywords = "Asteraceae, Melampolide, Nitric oxide production inhibitor, Sesquiterpene lactone, Smallanthus sonchifolius, Yacon",

author = "Hong, {Seong Su} and Lee, {Seon A.} and Han, {Xiang Hua} and Lee, {Min Hee} and Hwang, {Ji Sang} and Park, {Jeong Sook} and Oh, {Ki Wan} and Kun Han and Lee, {Myung Koo} and Heesoon Lee and Wook Kim and Dongho Lee and Hwang, {Bang Yeon}",

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doi = "10.1248/cpb.56.199",

language = "English",

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AU - Han, Xiang Hua

AU - Lee, Min Hee

AU - Hwang, Ji Sang

AU - Park, Jeong Sook

AU - Oh, Ki Wan

AU - Han, Kun

AU - Lee, Myung Koo

AU - Lee, Heesoon

AU - Kim, Wook

AU - Lee, Dongho

AU - Hwang, Bang Yeon

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KW - Asteraceae

KW - Melampolide

KW - Nitric oxide production inhibitor

KW - Sesquiterpene lactone

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KW - Yacon

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JF - Chemical and Pharmaceutical Bulletin

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ER -

Melampolides from the leaves of Smallanthus sonchifolius and their inhibitory activity of LPS-induced nitric oxide production

Abstract

Keywords

ASJC Scopus subject areas

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