Melanogenesis inhibitory bisabolane-type sesquiterpenoids from the roots of Angelica koreana

Jin Woo Lee; Cheong Yong Yun; Eunmiri Roh; Chul Lee; Qinghao Jin; Kwon Ki Bang; Sang Hun Jung; Dongho Lee; Mi Kyeong Lee; Youngsoo Kim; Bang Yeon Hwang

doi:10.1016/j.bmcl.2012.02.047

Melanogenesis inhibitory bisabolane-type sesquiterpenoids from the roots of Angelica koreana

Jin Woo Lee, Cheong Yong Yun, Eunmiri Roh, Chul Lee, Qinghao Jin, Kwon Ki Bang, Sang Hun Jung, Dongho Lee, Mi Kyeong Lee, Youngsoo Kim, Bang Yeon Hwang

Department of Biosystems and Biotechnology

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Bioactivity-guided isolation of the methanolic extract of the roots of Angelica koreana led to the isolation of four new bisabolane-type sesquiterpenoids, osterivolones A-D (1-4) together with four known compounds, bisabolangelone (5), decursinol angelate (6), psoralen (7), and falcarindiol (8). Their structures were elucidated on the basis of spectroscopic data interpretation, especially 2D NMR spectra such as HMQC, HMBC, and NOESY. All compounds were evaluated for their inhibitory effects of the melanogenesis against α-melanocyte stimulating hormone (α-MSH)-activated B16 melanoma cells.

Original language	English
Pages (from-to)	2927-2931
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	22
Issue number	8
DOIs	https://doi.org/10.1016/j.bmcl.2012.02.047
Publication status	Published - 2012 Apr 15

Bibliographical note

Funding Information:
This research was financially supported by a grant (R01-2007-000-20099-0) from the National Research Foundation of Korea. We thank the Korea Basic Science Institute for providing certain instruments used in this study.

Keywords

Angelica koreana
Bisabolane-type sesquiterpenoid
Melanogenesis inhibitor
Umbelliferae

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2012.02.047

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title = "Melanogenesis inhibitory bisabolane-type sesquiterpenoids from the roots of Angelica koreana",

abstract = "Bioactivity-guided isolation of the methanolic extract of the roots of Angelica koreana led to the isolation of four new bisabolane-type sesquiterpenoids, osterivolones A-D (1-4) together with four known compounds, bisabolangelone (5), decursinol angelate (6), psoralen (7), and falcarindiol (8). Their structures were elucidated on the basis of spectroscopic data interpretation, especially 2D NMR spectra such as HMQC, HMBC, and NOESY. All compounds were evaluated for their inhibitory effects of the melanogenesis against α-melanocyte stimulating hormone (α-MSH)-activated B16 melanoma cells.",

keywords = "Angelica koreana, Bisabolane-type sesquiterpenoid, Melanogenesis inhibitor, Umbelliferae",

author = "Lee, {Jin Woo} and Yun, {Cheong Yong} and Eunmiri Roh and Chul Lee and Qinghao Jin and Bang, {Kwon Ki} and Jung, {Sang Hun} and Dongho Lee and Lee, {Mi Kyeong} and Youngsoo Kim and Hwang, {Bang Yeon}",

note = "Funding Information: This research was financially supported by a grant (R01-2007-000-20099-0) from the National Research Foundation of Korea. We thank the Korea Basic Science Institute for providing certain instruments used in this study. ",

year = "2012",

month = apr,

day = "15",

doi = "10.1016/j.bmcl.2012.02.047",

language = "English",

volume = "22",

pages = "2927--2931",

journal = "Bioorganic and Medicinal Chemistry Letters",

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T1 - Melanogenesis inhibitory bisabolane-type sesquiterpenoids from the roots of Angelica koreana

AU - Lee, Jin Woo

AU - Yun, Cheong Yong

AU - Roh, Eunmiri

AU - Lee, Chul

AU - Jin, Qinghao

AU - Bang, Kwon Ki

AU - Jung, Sang Hun

AU - Lee, Dongho

AU - Lee, Mi Kyeong

AU - Kim, Youngsoo

AU - Hwang, Bang Yeon

N1 - Funding Information: This research was financially supported by a grant (R01-2007-000-20099-0) from the National Research Foundation of Korea. We thank the Korea Basic Science Institute for providing certain instruments used in this study.

PY - 2012/4/15

Y1 - 2012/4/15

N2 - Bioactivity-guided isolation of the methanolic extract of the roots of Angelica koreana led to the isolation of four new bisabolane-type sesquiterpenoids, osterivolones A-D (1-4) together with four known compounds, bisabolangelone (5), decursinol angelate (6), psoralen (7), and falcarindiol (8). Their structures were elucidated on the basis of spectroscopic data interpretation, especially 2D NMR spectra such as HMQC, HMBC, and NOESY. All compounds were evaluated for their inhibitory effects of the melanogenesis against α-melanocyte stimulating hormone (α-MSH)-activated B16 melanoma cells.

AB - Bioactivity-guided isolation of the methanolic extract of the roots of Angelica koreana led to the isolation of four new bisabolane-type sesquiterpenoids, osterivolones A-D (1-4) together with four known compounds, bisabolangelone (5), decursinol angelate (6), psoralen (7), and falcarindiol (8). Their structures were elucidated on the basis of spectroscopic data interpretation, especially 2D NMR spectra such as HMQC, HMBC, and NOESY. All compounds were evaluated for their inhibitory effects of the melanogenesis against α-melanocyte stimulating hormone (α-MSH)-activated B16 melanoma cells.

KW - Angelica koreana

KW - Bisabolane-type sesquiterpenoid

KW - Melanogenesis inhibitor

KW - Umbelliferae

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AN - SCOPUS:84862824406

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 8

ER -

Melanogenesis inhibitory bisabolane-type sesquiterpenoids from the roots of Angelica koreana

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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