Melanogenesis inhibitory bisabolane-type sesquiterpenoids from the roots of Angelica koreana

Jin Woo Lee, Cheong Yong Yun, Eunmiri Roh, Chul Lee, Qinghao Jin, Kwon Ki Bang, Sang Hun Jung, Dongho Lee, Mi Kyeong Lee, Youngsoo Kim, Bang Yeon Hwang

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Bioactivity-guided isolation of the methanolic extract of the roots of Angelica koreana led to the isolation of four new bisabolane-type sesquiterpenoids, osterivolones A-D (1-4) together with four known compounds, bisabolangelone (5), decursinol angelate (6), psoralen (7), and falcarindiol (8). Their structures were elucidated on the basis of spectroscopic data interpretation, especially 2D NMR spectra such as HMQC, HMBC, and NOESY. All compounds were evaluated for their inhibitory effects of the melanogenesis against α-melanocyte stimulating hormone (α-MSH)-activated B16 melanoma cells.

Original languageEnglish
Pages (from-to)2927-2931
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Issue number8
Publication statusPublished - 2012 Apr 15

Bibliographical note

Funding Information:
This research was financially supported by a grant (R01-2007-000-20099-0) from the National Research Foundation of Korea. We thank the Korea Basic Science Institute for providing certain instruments used in this study.


  • Angelica koreana
  • Bisabolane-type sesquiterpenoid
  • Melanogenesis inhibitor
  • Umbelliferae

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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