Melanogenesis inhibitory pregnane glycosides from Cynanchum atratum

Qinghao Jin, Xiang Hua Han, Cheong Yong Yun, Chul Lee, Jin Woo Lee, Dongho Lee, Mi Kyeong Lee, Sang Hun Jung, Jin Tae Hong, Youngsoo Kim, Bang Yeon Hwang

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Bioassay-guided fractionation of the methanolic extract from the roots of Cynanchum atratum has resulted in the isolation of three new pregnane glycosides (1–3) along with four known compounds (4–7). Their structures were identified by analysis of the spectroscopic data including extensive 2D NMR. All of the isolates were evaluated for their potential to inhibit the melanin production in α-melanocyte stimulating hormone (α-MSH)-activated B16 melanoma cells. Of these, compounds 4–7 dose-dependently inhibited the melanin production with the IC 50 values ranging from 4 μM to 33 μM.

Original languageEnglish
Pages (from-to)1252-1256
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Issue number7
Publication statusPublished - 2018 Apr 15

Bibliographical note

Funding Information:
This research was supported by a Medical Research Center Program ( MRC , 2017R1A5A2015541 ) through the National Research Foundation of Korea. The authors acknowledge the Korea Basic Science Institute for the NMR measurements.

Publisher Copyright:
© 2018 Elsevier Ltd


  • Asclepiadaceae
  • Cynanchum atratum
  • Melanogenesis inhibitor
  • Pregnane glycosides
  • α-MSH

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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