Abstract
Bioassay-guided fractionation of the methanolic extract from the roots of Cynanchum atratum has resulted in the isolation of three new pregnane glycosides (1–3) along with four known compounds (4–7). Their structures were identified by analysis of the spectroscopic data including extensive 2D NMR. All of the isolates were evaluated for their potential to inhibit the melanin production in α-melanocyte stimulating hormone (α-MSH)-activated B16 melanoma cells. Of these, compounds 4–7 dose-dependently inhibited the melanin production with the IC 50 values ranging from 4 μM to 33 μM.
Original language | English |
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Pages (from-to) | 1252-1256 |
Number of pages | 5 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 28 |
Issue number | 7 |
DOIs | |
Publication status | Published - 2018 Apr 15 |
Bibliographical note
Funding Information:This research was supported by a Medical Research Center Program ( MRC , 2017R1A5A2015541 ) through the National Research Foundation of Korea. The authors acknowledge the Korea Basic Science Institute for the NMR measurements.
Publisher Copyright:
© 2018 Elsevier Ltd
Keywords
- Asclepiadaceae
- Cynanchum atratum
- Melanogenesis inhibitor
- Pregnane glycosides
- α-MSH
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry