Enantioselective synthesis of quaternary α-amino acids based on alkylation of a conformationally unstable enolate according to a memory-of-chirality strategy was successfully adapted to a flow-based system. This allows for the scale-up of this enantioselective process with reaction residence times of less than three minutes. The enantiomeric excess values are similar to those obtained in the batch process.
Bibliographical noteFunding Information:
This research was supported by the Ministère de l′Enseigne-ment Supérieur, de la Recherche et de l'Innovation (doctoral grant to A. M.).
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
- Amino acids
- Asymmetric synthesis
- Continuous flow
- Flash chemistry
- Flow chemistry
- Memory of chirality
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry