Mesenchymal Stem Cells for Enhanced Healing of the Medial Collateral Ligament of the Knee Joint

Chul Soo Lee; Ok Hee Jeon; Seung Beom Han; Ki Mo Jang

doi:10.3390/medicina59040725

Mesenchymal Stem Cells for Enhanced Healing of the Medial Collateral Ligament of the Knee Joint

Chul Soo Lee, Ok Hee Jeon, Seung Beom Han, Ki Mo Jang

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

Abstract

Background and Objectives: The medial collateral ligament (MCL) is one of the major supporting ligaments of the knee joint, and MCL injuries are common where excessive valgus loading is applied to the knee joint. Although most MCL injuries can be treated conservatively, healing of the MCL can take several weeks to months. Furthermore, once injured, the biomechanical properties of the healed MCL differ from those of the native MCL, resulting in an increased risk of re-injury and chronic remnant symptoms. Mesenchymal stem cells (MSCs), owing to their therapeutic potential, have been investigated in various musculoskeletal injuries, and some preclinical studies regarding MSC-based approaches in MCL injuries have shown promising results. Despite satisfactory results in preclinical studies, there is still a lack of clinical studies in the orthopedic literature. This article describes the basic knowledge of the MCL, standard treatments for MCL injuries, and recent studies regarding the application of MSCs for enhanced healing of the MCL. MSC-based approaches are expected to be a potential therapeutic option for enhanced healing of the MCL in the future.

Original language	English
Article number	725
Journal	Medicina (Lithuania)
Volume	59
Issue number	4
DOIs	https://doi.org/10.3390/medicina59040725
Publication status	Published - 2023 Apr

Bibliographical note

Funding Information:
This research was supported by the Technology Innovation Program (or Industrial Strategic Technology Development Program) (No. 20003688, Development of cosmeceutical and medical device platform using biodegradable metal patch delivering microcurrent) funded by the Ministry of Trade, Industry & Energy (MOTIE, Republic of Korea).

Publisher Copyright:
© 2023 by the authors.

Keywords

cell-based treatment
knee joint
ligament
ligament healing
medial collateral ligament
mesenchymal stem cell

ASJC Scopus subject areas

General Medicine

Access to Document

10.3390/medicina59040725

Cite this

@article{e63fa07e02bd454dbf0b24beae6ed903,

title = "Mesenchymal Stem Cells for Enhanced Healing of the Medial Collateral Ligament of the Knee Joint",

abstract = "Background and Objectives: The medial collateral ligament (MCL) is one of the major supporting ligaments of the knee joint, and MCL injuries are common where excessive valgus loading is applied to the knee joint. Although most MCL injuries can be treated conservatively, healing of the MCL can take several weeks to months. Furthermore, once injured, the biomechanical properties of the healed MCL differ from those of the native MCL, resulting in an increased risk of re-injury and chronic remnant symptoms. Mesenchymal stem cells (MSCs), owing to their therapeutic potential, have been investigated in various musculoskeletal injuries, and some preclinical studies regarding MSC-based approaches in MCL injuries have shown promising results. Despite satisfactory results in preclinical studies, there is still a lack of clinical studies in the orthopedic literature. This article describes the basic knowledge of the MCL, standard treatments for MCL injuries, and recent studies regarding the application of MSCs for enhanced healing of the MCL. MSC-based approaches are expected to be a potential therapeutic option for enhanced healing of the MCL in the future.",

keywords = "cell-based treatment, knee joint, ligament, ligament healing, medial collateral ligament, mesenchymal stem cell",

author = "Lee, {Chul Soo} and Jeon, {Ok Hee} and Han, {Seung Beom} and Jang, {Ki Mo}",

note = "Funding Information: This research was supported by the Technology Innovation Program (or Industrial Strategic Technology Development Program) (No. 20003688, Development of cosmeceutical and medical device platform using biodegradable metal patch delivering microcurrent) funded by the Ministry of Trade, Industry & Energy (MOTIE, Republic of Korea). Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = apr,

doi = "10.3390/medicina59040725",

language = "English",

volume = "59",

journal = "Medicina (Lithuania)",

issn = "1010-660X",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "4",

}

TY - JOUR

T1 - Mesenchymal Stem Cells for Enhanced Healing of the Medial Collateral Ligament of the Knee Joint

AU - Lee, Chul Soo

AU - Jeon, Ok Hee

AU - Han, Seung Beom

AU - Jang, Ki Mo

N1 - Funding Information: This research was supported by the Technology Innovation Program (or Industrial Strategic Technology Development Program) (No. 20003688, Development of cosmeceutical and medical device platform using biodegradable metal patch delivering microcurrent) funded by the Ministry of Trade, Industry & Energy (MOTIE, Republic of Korea). Publisher Copyright: © 2023 by the authors.

PY - 2023/4

Y1 - 2023/4

N2 - Background and Objectives: The medial collateral ligament (MCL) is one of the major supporting ligaments of the knee joint, and MCL injuries are common where excessive valgus loading is applied to the knee joint. Although most MCL injuries can be treated conservatively, healing of the MCL can take several weeks to months. Furthermore, once injured, the biomechanical properties of the healed MCL differ from those of the native MCL, resulting in an increased risk of re-injury and chronic remnant symptoms. Mesenchymal stem cells (MSCs), owing to their therapeutic potential, have been investigated in various musculoskeletal injuries, and some preclinical studies regarding MSC-based approaches in MCL injuries have shown promising results. Despite satisfactory results in preclinical studies, there is still a lack of clinical studies in the orthopedic literature. This article describes the basic knowledge of the MCL, standard treatments for MCL injuries, and recent studies regarding the application of MSCs for enhanced healing of the MCL. MSC-based approaches are expected to be a potential therapeutic option for enhanced healing of the MCL in the future.

AB - Background and Objectives: The medial collateral ligament (MCL) is one of the major supporting ligaments of the knee joint, and MCL injuries are common where excessive valgus loading is applied to the knee joint. Although most MCL injuries can be treated conservatively, healing of the MCL can take several weeks to months. Furthermore, once injured, the biomechanical properties of the healed MCL differ from those of the native MCL, resulting in an increased risk of re-injury and chronic remnant symptoms. Mesenchymal stem cells (MSCs), owing to their therapeutic potential, have been investigated in various musculoskeletal injuries, and some preclinical studies regarding MSC-based approaches in MCL injuries have shown promising results. Despite satisfactory results in preclinical studies, there is still a lack of clinical studies in the orthopedic literature. This article describes the basic knowledge of the MCL, standard treatments for MCL injuries, and recent studies regarding the application of MSCs for enhanced healing of the MCL. MSC-based approaches are expected to be a potential therapeutic option for enhanced healing of the MCL in the future.

KW - cell-based treatment

KW - knee joint

KW - ligament

KW - ligament healing

KW - medial collateral ligament

KW - mesenchymal stem cell

UR - http://www.scopus.com/inward/record.url?scp=85156154712&partnerID=8YFLogxK

U2 - 10.3390/medicina59040725

DO - 10.3390/medicina59040725

M3 - Review article

C2 - 37109683

AN - SCOPUS:85156154712

SN - 1010-660X

VL - 59

JO - Medicina (Lithuania)

JF - Medicina (Lithuania)

IS - 4

M1 - 725

ER -

Mesenchymal Stem Cells for Enhanced Healing of the Medial Collateral Ligament of the Knee Joint

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this