Mesenchymal Stem Cells for Enhanced Healing of the Medial Collateral Ligament of the Knee Joint

Chul Soo Lee, Ok Hee Jeon, Seung Beom Han, Ki Mo Jang

Research output: Contribution to journalReview articlepeer-review


Background and Objectives: The medial collateral ligament (MCL) is one of the major supporting ligaments of the knee joint, and MCL injuries are common where excessive valgus loading is applied to the knee joint. Although most MCL injuries can be treated conservatively, healing of the MCL can take several weeks to months. Furthermore, once injured, the biomechanical properties of the healed MCL differ from those of the native MCL, resulting in an increased risk of re-injury and chronic remnant symptoms. Mesenchymal stem cells (MSCs), owing to their therapeutic potential, have been investigated in various musculoskeletal injuries, and some preclinical studies regarding MSC-based approaches in MCL injuries have shown promising results. Despite satisfactory results in preclinical studies, there is still a lack of clinical studies in the orthopedic literature. This article describes the basic knowledge of the MCL, standard treatments for MCL injuries, and recent studies regarding the application of MSCs for enhanced healing of the MCL. MSC-based approaches are expected to be a potential therapeutic option for enhanced healing of the MCL in the future.

Original languageEnglish
Article number725
JournalMedicina (Lithuania)
Issue number4
Publication statusPublished - 2023 Apr

Bibliographical note

Funding Information:
This research was supported by the Technology Innovation Program (or Industrial Strategic Technology Development Program) (No. 20003688, Development of cosmeceutical and medical device platform using biodegradable metal patch delivering microcurrent) funded by the Ministry of Trade, Industry & Energy (MOTIE, Republic of Korea).

Publisher Copyright:
© 2023 by the authors.


  • cell-based treatment
  • knee joint
  • ligament
  • ligament healing
  • medial collateral ligament
  • mesenchymal stem cell

ASJC Scopus subject areas

  • General Medicine


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