Meta-analyses of associations between interleukin-10 polymorphisms and susceptibility to recurrent pregnancy loss

Objective The aim of this study was to investigate whether interleukin-10 (IL-10) polymorphisms are associated with susceptibility to recurrent pregnancy loss (RPL). Methods We conducted a literature search using the PubMed and EMBASE databases and performed meta-analyses on the associations between IL-10 -1082 G/A, -819 C/T, and -592 C/A polymorphisms and RPL, using fixed- or random-effects models. Results A total of 15 papers involving 1858 RPL patients and 1949 controls were considered in this study. Meta-analysis of IL-10 -1082 G/A polymorphism revealed no association between RPL and the IL-10 -1082 G allele (OR = 0.999, 95% CI = 0.815-1.223, p = 0.989). However, meta-analysis of IL-10 -819 C/T polymorphism in all study subjects revealed an association between RPL and the IL-10 -819 C allele (OR = 0.680, 95% CI = 0.498-0.927, p = 0.015). Stratification by ethnicity indicated an association between the IL-10 -819 C allele and RPL in the Asian group (OR = 0.421, 95% CI = 0.226-0.783, p = 0.006), but not in the Caucasian and Arab groups (OR = 1.053, 95% CI = 0.218-5.077, p = 0.949, and OR = 0.800, 95% CI = 0.606-1.081, p = 0.152, respectively). Furthermore, a relationship between the IL-10 -592 C allele and RPL was identified in the Asian group (OR = 0.763, 95% CI = 0.633-0.919, p = 0.004), but not in the Caucasian and Arab groups. Conclusions The meta-analyses demonstrate that IL-10 -819 C/T and -592 C/A polymorphisms are associated with RPL susceptibility in Asian women, but not in the Caucasian and Arab populations.