Meta-analysis of associations between MTHFR and GST polymorphisms and susceptibility to multiple sclerosis

Young Ho Lee, Young Ho Seo, Jae Hoon Kim, Sung Jae Choi, Jong Dae Ji, Gwan Gyu Song

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


We examined whether methylenetetrahydrofolate reductase (MTHFR) and glutathione S-transferase (GST) polymorphisms are associated with susceptibility to multiple sclerosis (MS). We performed a meta-analysis on the association between MS and the following genotypes: MTHFR C677T, A1298C, and GSTP1 A313G polymorphisms, and GSTM1 and GSTT1 null alleles. Fifteen comparisons involving 2,486 patients and 2,861 controls were considered. Meta-analysis of all study subjects considered together showed no association between MS and the MTHFR 677 T allele (OR = 1.014, 95 % CI 0.803–1.280, p = 0.909). Stratification by ethnicity showed no similar association in Caucasian and Arab populations. Likewise, no link was found between MS and the MTHFR 1298 C allele in the total data (OR = 2.477, 95 % CI 0.507–12.10, p = 0.263), nor when it was stratified by ethnicity. No association with MS was observed in relation to the GSTM1 null genotype in Caucasian populations (OR = 1.229, 95 % CI 0.693–2.181, p = 0.481), nor with the GSTP1 A313G polymorphism (OR for G allele = 1.133, 95 % CI 0.903–1.421, p = 0.281). However, there was an association between MS and the GSTT1 null genotype in data obtained from Caucasian populations (OR = 1.945, 95 % CI 1.452–2.605, p = 8.6 × 10−7). GSTT1 null genotype is associated with MS in Caucasian populations; however, no association was found between MS and polymorphisms of MTHFR, GSTM1, and GSTP1.

Original languageEnglish
Pages (from-to)2089-2096
Number of pages8
JournalNeurological Sciences
Issue number11
Publication statusPublished - 2015 Jul 7
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2015, Springer-Verlag Italia.


  • GSTs
  • Meta-analysis
  • Multiple sclerosis
  • Polymorphism

ASJC Scopus subject areas

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health


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