TY - JOUR
T1 - Meta-analysis of the family-based association between the PTPN22 C1858T polymorphism and Type 1 diabetes
AU - Lee, Young Ho
AU - Song, Gwan Gyu
N1 - Funding Information:
Acknowledgments This study was supported by a grant from the Korea University Medical Center.
PY - 2013/1
Y1 - 2013/1
N2 - The aim of this study was to determine whether the functional protein tyrosine phosphatase nonreceptor 22 (PTPN22) C1858T polymorphism (rs2476601) confers susceptibility to type 1 diabetes (T1D). We conducted a meta-analysis of the transmission disequilibrium test (TDT) examining preferential transmission of the T allele of the PTPN22 C1858T polymorphism to children with T1D. A total of 11 studies were included in this meta-analysis, which contained 3,946 families and 2,024 transmissions of the PTPN22 T allele in 11 European populations. The frequencies of the transmitted and non-transmitted T allele were 1,250 (61.8%) and 774 (38.2%), respectively. The T allele was transmitted to T1D offspring more often than expected. Meta-analysis showed a significant association between the PTPN22 T allele and T1D (OR 1.611, 95% CI 1.421, 1.827, p<1×10-8) without between-study heterogeneity (I 2=32.5, p=0.138). Publication bias was observed in this meta-analysis (Egger's regression test, p-values=0.061), but the adjusted OR calculated using the trim and fill technique remained significant (OR 1.577, 95% CI 1.392, 1.785). This meta-analysis of TDT confirms that the PTPN22 C1858T polymorphism is associated with T1D susceptibility in Europeans.
AB - The aim of this study was to determine whether the functional protein tyrosine phosphatase nonreceptor 22 (PTPN22) C1858T polymorphism (rs2476601) confers susceptibility to type 1 diabetes (T1D). We conducted a meta-analysis of the transmission disequilibrium test (TDT) examining preferential transmission of the T allele of the PTPN22 C1858T polymorphism to children with T1D. A total of 11 studies were included in this meta-analysis, which contained 3,946 families and 2,024 transmissions of the PTPN22 T allele in 11 European populations. The frequencies of the transmitted and non-transmitted T allele were 1,250 (61.8%) and 774 (38.2%), respectively. The T allele was transmitted to T1D offspring more often than expected. Meta-analysis showed a significant association between the PTPN22 T allele and T1D (OR 1.611, 95% CI 1.421, 1.827, p<1×10-8) without between-study heterogeneity (I 2=32.5, p=0.138). Publication bias was observed in this meta-analysis (Egger's regression test, p-values=0.061), but the adjusted OR calculated using the trim and fill technique remained significant (OR 1.577, 95% CI 1.392, 1.785). This meta-analysis of TDT confirms that the PTPN22 C1858T polymorphism is associated with T1D susceptibility in Europeans.
KW - Meta-analysis
KW - Polymorphism
KW - Protein tyrosine phosphatase nonreceptor 22
KW - Type 1 diabetes
UR - http://www.scopus.com/inward/record.url?scp=84871309395&partnerID=8YFLogxK
U2 - 10.1007/s11033-012-2051-8
DO - 10.1007/s11033-012-2051-8
M3 - Article
C2 - 23054006
AN - SCOPUS:84871309395
SN - 0301-4851
VL - 40
SP - 211
EP - 215
JO - Molecular biology reports
JF - Molecular biology reports
IS - 1
ER -
