Metabolic regulation of ferroptosis in cancer

Min Ji Kim, Greg Jiho Yun, Sung Eun Kim

Research output: Contribution to journalReview articlepeer-review

35 Citations (Scopus)

Abstract

Ferroptosis is a unique cell death mechanism that is executed by the excessive accumulation of lipid peroxidation in cells. The relevance of ferroptosis in multiple human diseases such as neurodegeneration, organ damage, and cancer is becoming increasingly evident. As ferroptosis is deeply intertwined with metabolic pathways such as iron, cyst(e)ine, glutathione, and lipid metab-olism, a better understanding of how ferroptosis is regulated by these pathways will enable the precise utilization or prevention of ferroptosis for therapeutic uses. In this review, we present an update of the mechanisms underlying diverse metabolic pathways that can regulate ferroptosis in cancer.

Original languageEnglish
Article number83
Pages (from-to)1-21
Number of pages21
JournalBiology
Volume10
Issue number2
DOIs
Publication statusPublished - 2021 Feb

Bibliographical note

Funding Information:
Funding: This work was supported by the Korean NRF Grant 2020R1C1C1013220 and Korea University Grant K1924741, K1926621, and K2007501 (S.E.K.).

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • Cyst(e)ine metabolism
  • Ferroptosis
  • GPX4
  • Glutathione metabolism
  • Iron metabolism
  • Lipid peroxidation
  • Reactive oxygen species
  • SLC7A11

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology
  • General Immunology and Microbiology
  • General Agricultural and Biological Sciences

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