Metabolic syndrome in the non-pregnant state is associated with the development of preeclampsia

Geum Joon Cho, Jong Heon Park, Soon Ae Shin, Min Jeong Oh, Hong Seog Seo

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    16 Citations (Scopus)


    Background The aim of this study was to investigate the association between metabolic syndrome in the non-pregnant state and the development of preeclampsia. Methods We enrolled 212,463 Korean women who had their first delivery between January, 2011 and December, 2012 and had undergone a national health screening examination through the National Health Insurance during the 1-2 years before their first delivery. Women who had hypertension in the non-pregnant state were excluded. The presence of metabolic syndrome was defined using the modified criteria published in National Cholesterol Education Program Adult Treatment Panel III criteria. Results The prevalence of metabolic syndrome in non-pregnant state was 1.2%. Preeclampsia developed in 3.1% and its prevalence among women with and without metabolic syndrome was 7.3% and 3.0%, respectively. The pre-pregnancy prevalence of metabolic syndrome was higher in women who developed preeclampsia compared to that in those who had a normal pregnancy (1.1% vs. 2.8%; p < 0.001). On multivariate regression analysis, women with metabolic syndrome had an increased risk of developing preeclampsia (odds ratio: 1.48; 95% CI: 1.26 to 1.74) compared to that in those without metabolic syndrome, after adjusting for age, family history of hypertension, smoking status, and pre-pregnancy body mass index. The risk of preeclampsia increased with a rise in the number of components of metabolic syndrome. Conclusion Metabolic syndrome in the non-pregnant state was associated with the development of preeclampsia. Further studies are needed to evaluate whether early intervention for metabolic syndrome before pregnancy can decrease the risk of developing preeclampsia.

    Original languageEnglish
    Pages (from-to)982-986
    Number of pages5
    JournalInternational Journal of Cardiology
    Publication statusPublished - 2016 Jan 15

    Bibliographical note

    Funding Information:
    Sources of funding: This study was partly supported by KU-KIST Graduate School Converging Science and Technology Program ( R1435291 ), the Korea Institute of Science and Technology Institutional Program (Project No. 2E24080 ), and the National Research Foundation of Korea Grant funded by the Korean Government ( NRF-2012R1A1A1044719 ).

    Publisher Copyright:
    © 2015 Elsevier Ireland Ltd. All rights reserved.


    • Hypertension
    • Metabolic syndrome
    • Pre-pregnancy
    • Preeclampsia

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine


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