Metformin inhibits tumor cell migration via down-regulation of MMP9 in tamoxifen-resistant breast cancer cells

Soon Young Jang, Aeree Kim, Jin Kyoung Kim, Chungyel Kim, Youl Hee Cho, Jong Ho Kim, Chul Hwan Kim, Ji Yun Lee

    Research output: Contribution to journalArticlepeer-review

    35 Citations (Scopus)

    Abstract

    Metformin is the most widely used anti-diabetic drug in the world. Recent evidence indicates that metformin could potentially inhibit tumorigenesis. In the present study, we found that metformin inhibited cell migration and invasion of phorbol 12-myristate 13-acetate-induced MCF-7 and tamoxifen-resistant MCF-7 breast cancer cells. This inhibition was correlated with the modulation of matrix metalloproteinase-9 (MMP9) via the suppression of its expression and proteolytic activity. These results indicate that metformin leads to the suppression of migration and invasion through regulation of MMP9 and it may have potential as an anticancer drug for therapy in human breast cancer, especially of chemoresistant cancer cells.

    Original languageEnglish
    Pages (from-to)4127-4134
    Number of pages8
    JournalAnticancer research
    Volume34
    Issue number8
    Publication statusPublished - 2014 Aug 1

    Bibliographical note

    Publisher Copyright:
    © 2014, International Institute of Anticancer Research. All rights reserved.

    Keywords

    • Invasion
    • MMP9
    • Metformin
    • Migration
    • Tamoxifen resistance

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

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