Abstract
Metformin is the most widely used anti-diabetic drug in the world. Recent evidence indicates that metformin could potentially inhibit tumorigenesis. In the present study, we found that metformin inhibited cell migration and invasion of phorbol 12-myristate 13-acetate-induced MCF-7 and tamoxifen-resistant MCF-7 breast cancer cells. This inhibition was correlated with the modulation of matrix metalloproteinase-9 (MMP9) via the suppression of its expression and proteolytic activity. These results indicate that metformin leads to the suppression of migration and invasion through regulation of MMP9 and it may have potential as an anticancer drug for therapy in human breast cancer, especially of chemoresistant cancer cells.
| Original language | English |
|---|---|
| Pages (from-to) | 4127-4134 |
| Number of pages | 8 |
| Journal | Anticancer research |
| Volume | 34 |
| Issue number | 8 |
| Publication status | Published - 2014 Aug 1 |
Bibliographical note
Publisher Copyright:© 2014, International Institute of Anticancer Research. All rights reserved.
Keywords
- Invasion
- MMP9
- Metformin
- Migration
- Tamoxifen resistance
ASJC Scopus subject areas
- Oncology
- Cancer Research
