Metformin inhibits tumor cell migration via down-regulation of MMP9 in tamoxifen-resistant breast cancer cells

Soon Young Jang; Aeree Kim; Jin Kyoung Kim; Chungyel Kim; Youl Hee Cho; Jong Ho Kim; Chul Hwan Kim; Ji Yun Lee

Metformin inhibits tumor cell migration via down-regulation of MMP9 in tamoxifen-resistant breast cancer cells

Soon Young Jang, Aeree Kim, Jin Kyoung Kim, Chungyel Kim, Youl Hee Cho, Jong Ho Kim, Chul Hwan Kim, Ji Yun Lee

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Metformin is the most widely used anti-diabetic drug in the world. Recent evidence indicates that metformin could potentially inhibit tumorigenesis. In the present study, we found that metformin inhibited cell migration and invasion of phorbol 12-myristate 13-acetate-induced MCF-7 and tamoxifen-resistant MCF-7 breast cancer cells. This inhibition was correlated with the modulation of matrix metalloproteinase-9 (MMP9) via the suppression of its expression and proteolytic activity. These results indicate that metformin leads to the suppression of migration and invasion through regulation of MMP9 and it may have potential as an anticancer drug for therapy in human breast cancer, especially of chemoresistant cancer cells.

Original language	English
Pages (from-to)	4127-4134
Number of pages	8
Journal	Anticancer research
Volume	34
Issue number	8
Publication status	Published - 2014 Aug 1

Keywords

Invasion
MMP9
Metformin
Migration
Tamoxifen resistance

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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abstract = "Metformin is the most widely used anti-diabetic drug in the world. Recent evidence indicates that metformin could potentially inhibit tumorigenesis. In the present study, we found that metformin inhibited cell migration and invasion of phorbol 12-myristate 13-acetate-induced MCF-7 and tamoxifen-resistant MCF-7 breast cancer cells. This inhibition was correlated with the modulation of matrix metalloproteinase-9 (MMP9) via the suppression of its expression and proteolytic activity. These results indicate that metformin leads to the suppression of migration and invasion through regulation of MMP9 and it may have potential as an anticancer drug for therapy in human breast cancer, especially of chemoresistant cancer cells.",

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T1 - Metformin inhibits tumor cell migration via down-regulation of MMP9 in tamoxifen-resistant breast cancer cells

AU - Jang, Soon Young

AU - Kim, Aeree

AU - Kim, Jin Kyoung

AU - Kim, Chungyel

AU - Cho, Youl Hee

AU - Kim, Jong Ho

AU - Kim, Chul Hwan

AU - Lee, Ji Yun

PY - 2014/8/1

Y1 - 2014/8/1

N2 - Metformin is the most widely used anti-diabetic drug in the world. Recent evidence indicates that metformin could potentially inhibit tumorigenesis. In the present study, we found that metformin inhibited cell migration and invasion of phorbol 12-myristate 13-acetate-induced MCF-7 and tamoxifen-resistant MCF-7 breast cancer cells. This inhibition was correlated with the modulation of matrix metalloproteinase-9 (MMP9) via the suppression of its expression and proteolytic activity. These results indicate that metformin leads to the suppression of migration and invasion through regulation of MMP9 and it may have potential as an anticancer drug for therapy in human breast cancer, especially of chemoresistant cancer cells.

AB - Metformin is the most widely used anti-diabetic drug in the world. Recent evidence indicates that metformin could potentially inhibit tumorigenesis. In the present study, we found that metformin inhibited cell migration and invasion of phorbol 12-myristate 13-acetate-induced MCF-7 and tamoxifen-resistant MCF-7 breast cancer cells. This inhibition was correlated with the modulation of matrix metalloproteinase-9 (MMP9) via the suppression of its expression and proteolytic activity. These results indicate that metformin leads to the suppression of migration and invasion through regulation of MMP9 and it may have potential as an anticancer drug for therapy in human breast cancer, especially of chemoresistant cancer cells.

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KW - MMP9

KW - Metformin

KW - Migration

KW - Tamoxifen resistance

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AN - SCOPUS:84908669583

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JO - Anticancer research

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ER -

Metformin inhibits tumor cell migration via down-regulation of MMP9 in tamoxifen-resistant breast cancer cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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