Metformin prevents endoplasmic reticulum stress-induced apoptosis through AMPK-PI3K-c-Jun NH ₂ pathway

Keyphrases

• Phosphoinositide 3-kinase (PI3K) 100%
• AMP-activated Protein Kinase 100%
• C-Jun 100%
• Metformin 100%
• Endoplasmic Reticulum Stress-induced Apoptosis 100%
• NIT-1 Cells 71%
• Endoplasmic Reticulum Stress (ER stress) 57%
• Pancreatic β-cells 42%
• Cell Death 28%
• C-Jun N-terminal Kinase 28%
• Stress-induced 28%
• Type 2 Diabetes Mellitus (T2DM) 14%
• Insulin Secretion 14%
• Phosphorylation 14%
• Endoplasmic Reticulum 14%
• Inhibitor of Apoptosis Proteins 14%
• Kinase Cascade 14%
• Insulin Sensitizers 14%
• Phosphatidylinositol 3-kinase Inhibitor 14%
• Beta Cell Line 14%
• Kinase Activation 14%
• Protective Effect 14%
• Cell Function 14%
• Unfolded Protein Response 14%
• Cell Resistance 14%
• Cell Dysfunction 14%
• Insulin Synthesis 14%
• β-cell Dysfunction 14%

Medicine and Dentistry

• Programmed Cell Death 100%
• Endoplasmic Reticulum Stress 100%
• Hydroxymethylglutaryl Coenzyme A Reductase Kinase 100%
• Glycon 100%
• Beta Cell 42%
• Phosphotransferase 28%
• Phosphoinositide 3-Kinase 28%
• Cell Death 14%
• Cell Line 14%
• Phosphoinositide 3-Kinase Inhibitor 14%
• Protein Kinase C 14%
• Maturity Onset Diabetes of the Young 14%
• Insulin Release 14%
• Cell Function 14%
• Endoplasmic reticulum 14%
• Unfolded Protein Response 14%
• Insulin Sensitizing Agent 14%
• Insulin Synthesis 14%
• Cell Destruction 14%

Pharmacology, Toxicology and Pharmaceutical Science

• Hydroxymethylglutaryl Coenzyme A Reductase Kinase 100%
• Metformin 100%
• Phosphotransferase 28%
• Phosphatidylinositol 3 Kinase 28%
• Protein Kinase C 14%
• Phosphatidylinositol 3 Kinase Inhibitor 14%
• Insulin Sensitizing Agent 14%
• Non Insulin Dependent Diabetes Mellitus 14%