Method for In-Vivo Fluorescence Imaging Contrast Enhancement through Light Modulation

Jaeyoung Kim, Onseok Lee, Seunghan Ha, Jung Woo Lee, Chil Hwan Oh

    Research output: Contribution to journalArticlepeer-review


    Early diagnosis is one of the most important factors that increase the therapeutic potential of the disease. Diagnoses conducted by conventional equipment are expensive, time-consuming, burdensome to patients, and do not have high success rates. Diagnostic methods have also been investigated using nanoparticles. However, there have been no significant improvements in the early diagnosis of disease. The diagnosis technique proposed in this paper consumes less time, is more cost-effective, and more accurate. It uses a new concept—a low-intensity fluorescence molecular imaging system with a lock-in technique. This study applied the lock-in technique to basic research in contrast enhancement and optimization. This improved fluorescence distribution analysis, resulting in increased resolution of optical molecular imaging for early diagnosis of disease. An experimental lock-in fluorescence imaging system, which used a variety of fluorescent dyes, achieved signal amplification 100 times greater than that of a conventional fluorescence imaging system. The results of this study demonstrate that the lock-in technique could significantly improve optical molecular imaging technology, making it possible to achieve early diagnosis of disease.

    Original languageEnglish
    Pages (from-to)13-20
    Number of pages8
    JournalJournal of Fluorescence
    Issue number1
    Publication statusPublished - 2017 Jan 1


    • Contrast enhancement
    • Fluorescent dye
    • Lock-in technique
    • Nanoparticle

    ASJC Scopus subject areas

    • Biochemistry
    • Clinical Psychology
    • Social Sciences (miscellaneous)
    • Sociology and Political Science
    • Spectroscopy
    • Clinical Biochemistry
    • Law


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