Micellar phytosterols effectively reduce cholesterol absorption at low doses

Min Jeong Shin, Ho Lee Jong, Yangsoo Jang, Cha Lee Kim Yang, Eunju Park, Mee Kim Kyung, Chul Chung Bong, Namsik Chung

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


Background: The objective of this study was to evaluate the effects of micellar phytosterols on cholesterol absorption in humans. Methods: 24 healthy adults (mean age 37 years, 16 women and 8 men) underwent four cholesterol-absorption tests to compare the effects of micellar phytosterols supplement containing 500, 300, 200 mg phytosterols and placebo on cholesterol absorption in a cross-over design. Individual absorption tests were separated by 2 weeks. Using the single oral isotope method, inhibition of cholesterol absorption was determined by gas-chromatography mass spectrometry measurement of the differences in plasma hexadeuterated cholesterol enrichment 4 days after test meals with or without phytosterols. Each test meal provided 500 kcal and 89 mg cholesterol including 40 mg tracer cholesterol. We used a general linear mixed model with SAS to test the significance of treatment effect. Results: Micellar phytosterols had a significant overall effect on cholesterol absorption (p = 0.0002), reduced cholesterol absorption by 23.3% at a dose of 300 mg phytosterols (p = 0.0004) and by 32.0% at a dose of 500 mg phytosterols (p = 0.0001) compared with the placebo. The effect of 200 mg treatment did not reach statistical significance but there was a tendency (p = 0.052). Conclusion: Water-dispersible, micellar phytosterols reduced cholesterol absorption effectively at very low doses.

Original languageEnglish
Pages (from-to)346-351
Number of pages6
JournalAnnals of Nutrition and Metabolism
Issue number5
Publication statusPublished - 2005 Sept
Externally publishedYes


  • Cholesterol absorption
  • Hexadeuterated cholesterol
  • Phytosterols

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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