Micelle behavior of copolymers composed of linear and hyperbranched blocks in aqueous solution

Su Hoon Lim, Eui Joon Cha, June Huh, Cheol Hee Ahn

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Multi-arm poly(THF)-b-polyglycerol linear-hyperbranched copolymers consisting of a linear hydrophobic poly(THF) block and a hyperbranched hydrophilic polyglycerol block were synthesized by ring opening polymerization of tetrahydrofuran with silver trifluoromethane sulfonate as a catalyst and the consecutive polymerization of glycidol. Initiators with different geometries that propagated into different numbers of arms (e.g., 1, 2 or 4) were used to investigate the dependence of the micelle properties of the copolymers on the number of arms. The critical micelle concentration (CMC) first decreased and then increased with increasing numbers of arms showing a minimum CMC at an arm number of 2. A minimum CMC was difficult to obtain using multi-arm block copolymers composed of linear polymers with the small number of arms investigated in this study. DLS showed that the 4-arm poly(THF)-b-polygly- cerol copolymer had a micelle size of approximately 83 nm under aqueous conditions, and the micelle size of the copolymers with different numbers of arms was similar. Unimolecular micelles could eventually be obtained using this system by increasing the number of arms, they are considered an ideal drug delivery carrier due to the concentration-independent stability in the blood stream.

Original languageEnglish
Pages (from-to)1734-1738
Number of pages5
JournalMacromolecular Chemistry and Physics
Issue number20
Publication statusPublished - 2009 Oct 22
Externally publishedYes


  • Block copolymers
  • Hyperbranched
  • Micelles
  • Ring-opening polymerization

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry


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