Microalgal secondary metabolite productions as a component of biorefinery: A review

Yun Hwan Park, Sang Il Han, Byeolnim Oh, Hyun Soo Kim, Min Seo Jeon, Sok Kim, Yoon E. Choi

Research output: Contribution to journalReview articlepeer-review

18 Citations (Scopus)


The interest in developing microalgae for industrial use has been increasing because of concerns about the depletion of petroleum resources and securing sustainable energy sources. Microalgae have high biomass productivity and short culture periods. However, despite these advantages, various barriers need to be overcome for industrial applications. Microalgal cultivation has a high unit price, thus rendering industrial application difficult. It is indispensably necessary to co-produce their primary and secondary metabolites to compensate for these shortcomings. In this regard, this article reviews the following aspects, (1) co-production of primary and secondary metabolites in microalgae, (2) induction methods for the promotion of the biosynthesis of secondary metabolites, and (3) perspectives on the co-production and co-extraction of primary and secondary metabolites. This paper presents various approaches for producing useful metabolites from microalgae and suggests strategies that can be utilized for the co-production of primary and secondary metabolites.

Original languageEnglish
Article number126206
JournalBioresource technology
Publication statusPublished - 2022 Jan

Bibliographical note

Funding Information:
This work was supported by the Commercializations Promotion Agency for R&D Outcomes (COMPA) grant funded by the Korea government (MSIT) (No. 2021B300). This work was also supported by Korea Environment Industry & Technology Institute (KEITI) through Project to develop eco-friendly new materials and processing technology derived from wildlife, funded by Korea Ministry of Environment (MOE) (2021003280004 and 2021003240004). This research was supported by the Korea Basic Science Institute (KBSI) (Project No. C070300).

Publisher Copyright:
© 2021


  • Co-production & co-extraction
  • Metabolites induction
  • Microalgae
  • Primary metabolites
  • Secondary metabolites

ASJC Scopus subject areas

  • Bioengineering
  • Environmental Engineering
  • Renewable Energy, Sustainability and the Environment
  • Waste Management and Disposal


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