Abstract
In this paper, we developed microfluidic chip-based fiber spinning of poly(lactic-coglycolic acid). To make the poly glycolic-co-lactic acid(PLGA) micro fiber, the micro-channel based polydimetylsiloxane(PDMS) spinning device was fabricated, PLGA solution in dimethylsulfoxide (DMSO) and aqueous glycerol solution was used for fiber spinning. By controlling the sample and sheath flow condition, fiber could be made with various diameter from about 20um to 220um. PLGA fibers have dense surface morphology with few surface pore, whereas inside the fiber, highly porous structure with interconnected pores. In cell culture assay for tissue engineering scaffolds, cells were aligned along the fiber axis after 72 hr culture and no evidence of cytotoxic effect induced by the process.
| Original language | English |
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| Title of host publication | Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007 |
| Editors | Jean-Louis Viovy, Patrick Tabeling, Stephanie Descroix, Laurent Malaquin |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 778-780 |
| Number of pages | 3 |
| ISBN (Electronic) | 9780979806407 |
| Publication status | Published - 2007 |
| Externally published | Yes |
| Event | 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007 - Paris, France Duration: 2007 Oct 7 → 2007 Oct 11 |
Publication series
| Name | Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007 |
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Conference
| Conference | 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007 |
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| Country/Territory | France |
| City | Paris |
| Period | 07/10/7 → 07/10/11 |
Bibliographical note
Publisher Copyright:© 2007 CBMS.
Keywords
- PDMS microfluidic chip
- PLGA microfiber
- Phase inversion
- Tissue engineering scaffold
ASJC Scopus subject areas
- Chemical Engineering (miscellaneous)
- Bioengineering