Microfluidic fabrication of biocompatible poly(N-vinylcaprolactam)-based microcarriers for modulated thermo-responsive drug release

Yoon Ho Roh; Ju Yeon Moon; Eun Ji Hong; Hyeon Ung Kim; Min Suk Shim; Ki Wan Bong

doi:10.1016/j.colsurfb.2018.08.059

Microfluidic fabrication of biocompatible poly(N-vinylcaprolactam)-based microcarriers for modulated thermo-responsive drug release

Yoon Ho Roh, Ju Yeon Moon, Eun Ji Hong, Hyeon Ung Kim, Min Suk Shim, Ki Wan Bong

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Various thermo-responsive polymers have been developed for controlled drug delivery upon the local application of external heat. The development of thermo-responsive polymers of high biocompatibility and tunable thermo-sensitivity is crucial for safe and efficient therapeutic application. In this study, thermo-responsive drug carriers featuring tunable thermo-sensitivities were synthesized using biocompatible poly(N-vinyl caprolactam) (PVCL) and stop-flow lithography. The PVCL-based particles showed selective drug release depending on temperature, illustrating their feasibility for on-demand controlled drug delivery. The volume phase transition temperature (VPTT) of the PVCL-based particles can be adjusted to vary from room temperature to body temperature by controlling their monomer compositions. In addition, modulated drug release was achieved by constructing multicompartments of different thermo-sensitivities within the PVCL particles. To accomplish thermo-responsive anticancer therapy, doxorubicin (DOX) was encapsulated into the PVCL particles as an anticancer drug. The DOX-loaded PVCL particles exhibited both thermo-responsive drug release and anticancer activity. This study demonstrates that thermo-responsive PVCL particles are highly promising carriers for safe and targeted anticancer therapy.

Original language	English
Pages (from-to)	380-386
Number of pages	7
Journal	Colloids and Surfaces B: Biointerfaces
Volume	172
DOIs	https://doi.org/10.1016/j.colsurfb.2018.08.059
Publication status	Published - 2018 Dec 1

Bibliographical note

Funding Information:
This work has been supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF-2015R1C1A1A02037452), the Engineering Research Center of Excellence Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future planning (NRF-2016R1A5A1010148) and the grant from the Next-Generation Biogreen 21 Program (No. PJ013158), Rural Development Administration, Republic of Korea. This research was also supported by the National Research Foundation (NRF) funded by the Korean government (MSIT) (NRF-2017R1A4A1015036).

Publisher Copyright:
© 2018 Elsevier B.V.

Keywords

Anticancer therapy
Drug release
Poly(N-vinyl caprolactam)
Stop-flow lithography
Thermo-Responsive

ASJC Scopus subject areas

Biotechnology
Surfaces and Interfaces
Physical and Theoretical Chemistry
Colloid and Surface Chemistry

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10.1016/j.colsurfb.2018.08.059

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title = "Microfluidic fabrication of biocompatible poly(N-vinylcaprolactam)-based microcarriers for modulated thermo-responsive drug release",

abstract = "Various thermo-responsive polymers have been developed for controlled drug delivery upon the local application of external heat. The development of thermo-responsive polymers of high biocompatibility and tunable thermo-sensitivity is crucial for safe and efficient therapeutic application. In this study, thermo-responsive drug carriers featuring tunable thermo-sensitivities were synthesized using biocompatible poly(N-vinyl caprolactam) (PVCL) and stop-flow lithography. The PVCL-based particles showed selective drug release depending on temperature, illustrating their feasibility for on-demand controlled drug delivery. The volume phase transition temperature (VPTT) of the PVCL-based particles can be adjusted to vary from room temperature to body temperature by controlling their monomer compositions. In addition, modulated drug release was achieved by constructing multicompartments of different thermo-sensitivities within the PVCL particles. To accomplish thermo-responsive anticancer therapy, doxorubicin (DOX) was encapsulated into the PVCL particles as an anticancer drug. The DOX-loaded PVCL particles exhibited both thermo-responsive drug release and anticancer activity. This study demonstrates that thermo-responsive PVCL particles are highly promising carriers for safe and targeted anticancer therapy.",

keywords = "Anticancer therapy, Drug release, Poly(N-vinyl caprolactam), Stop-flow lithography, Thermo-Responsive",

author = "Roh, {Yoon Ho} and Moon, {Ju Yeon} and Hong, {Eun Ji} and Kim, {Hyeon Ung} and Shim, {Min Suk} and Bong, {Ki Wan}",

note = "Funding Information: This work has been supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF-2015R1C1A1A02037452), the Engineering Research Center of Excellence Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future planning (NRF-2016R1A5A1010148) and the grant from the Next-Generation Biogreen 21 Program (No. PJ013158), Rural Development Administration, Republic of Korea. This research was also supported by the National Research Foundation (NRF) funded by the Korean government (MSIT) (NRF-2017R1A4A1015036). Publisher Copyright: {\textcopyright} 2018 Elsevier B.V.",

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AU - Kim, Hyeon Ung

AU - Shim, Min Suk

AU - Bong, Ki Wan

N1 - Funding Information: This work has been supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF-2015R1C1A1A02037452), the Engineering Research Center of Excellence Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future planning (NRF-2016R1A5A1010148) and the grant from the Next-Generation Biogreen 21 Program (No. PJ013158), Rural Development Administration, Republic of Korea. This research was also supported by the National Research Foundation (NRF) funded by the Korean government (MSIT) (NRF-2017R1A4A1015036). Publisher Copyright: © 2018 Elsevier B.V.

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N2 - Various thermo-responsive polymers have been developed for controlled drug delivery upon the local application of external heat. The development of thermo-responsive polymers of high biocompatibility and tunable thermo-sensitivity is crucial for safe and efficient therapeutic application. In this study, thermo-responsive drug carriers featuring tunable thermo-sensitivities were synthesized using biocompatible poly(N-vinyl caprolactam) (PVCL) and stop-flow lithography. The PVCL-based particles showed selective drug release depending on temperature, illustrating their feasibility for on-demand controlled drug delivery. The volume phase transition temperature (VPTT) of the PVCL-based particles can be adjusted to vary from room temperature to body temperature by controlling their monomer compositions. In addition, modulated drug release was achieved by constructing multicompartments of different thermo-sensitivities within the PVCL particles. To accomplish thermo-responsive anticancer therapy, doxorubicin (DOX) was encapsulated into the PVCL particles as an anticancer drug. The DOX-loaded PVCL particles exhibited both thermo-responsive drug release and anticancer activity. This study demonstrates that thermo-responsive PVCL particles are highly promising carriers for safe and targeted anticancer therapy.

AB - Various thermo-responsive polymers have been developed for controlled drug delivery upon the local application of external heat. The development of thermo-responsive polymers of high biocompatibility and tunable thermo-sensitivity is crucial for safe and efficient therapeutic application. In this study, thermo-responsive drug carriers featuring tunable thermo-sensitivities were synthesized using biocompatible poly(N-vinyl caprolactam) (PVCL) and stop-flow lithography. The PVCL-based particles showed selective drug release depending on temperature, illustrating their feasibility for on-demand controlled drug delivery. The volume phase transition temperature (VPTT) of the PVCL-based particles can be adjusted to vary from room temperature to body temperature by controlling their monomer compositions. In addition, modulated drug release was achieved by constructing multicompartments of different thermo-sensitivities within the PVCL particles. To accomplish thermo-responsive anticancer therapy, doxorubicin (DOX) was encapsulated into the PVCL particles as an anticancer drug. The DOX-loaded PVCL particles exhibited both thermo-responsive drug release and anticancer activity. This study demonstrates that thermo-responsive PVCL particles are highly promising carriers for safe and targeted anticancer therapy.

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JO - Colloids and Surfaces B: Biointerfaces

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ER -

Microfluidic fabrication of biocompatible poly(N-vinylcaprolactam)-based microcarriers for modulated thermo-responsive drug release

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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