Microfluidic fabrication of fatty alcohol-based microparticles for NIR light-triggered drug release

Hyeon Ung Kim; Yoon Ho Roh; Min Suk Shim; Ki Wan Bong

doi:10.1016/j.jiec.2019.06.047

Microfluidic fabrication of fatty alcohol-based microparticles for NIR light-triggered drug release

Hyeon Ung Kim, Yoon Ho Roh, Min Suk Shim, Ki Wan Bong

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

The development of photo-triggered drug delivery system is promising for the temporal and spatial control of drug release. However, most of the progress in photothermal drug delivery has been focused on nanosized particles which can be removed from the injected sites by exocytosis. In this study, injectable and implantable near-infrared (NIR) light-responsive microparticles are fabricated using droplet-based microfluidics. The particles are composed of 1-tetradecanol, as a class of non-toxic phase change material, and IR780, as a NIR-absorbing photothermal agent. Doxorubicin, an anticancer drug, is encapsulated in the particles to obtain NIR light-responsive anticancer drug carriers. The photothermal response of IR780 to NIR irradiation facilitates the release of the encapsulated drug through the melting of 1-tetradecanol and demonstrates the NIR light-responsive drug release. This study shows that IR780-encapsulated 1-tetradecanol microparticles fabricated by droplet-based microfluidics have great potential as injectable and implantable drug carriers featuring NIR light-sensitive drug release.

Original language	English
Pages (from-to)	778-783
Number of pages	6
Journal	Journal of Industrial and Engineering Chemistry
Volume	80
DOIs	https://doi.org/10.1016/j.jiec.2019.06.047
Publication status	Published - 2019 Dec 25

Bibliographical note

Funding Information:
This work was supported by the Engineering Research Center of Excellence Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning ( NRF-2016R1A5A1010148 ) This work was also supported by the Incheon National University Research Grant in 2016.

Funding Information:
This work was supported by the Engineering Research Center of Excellence Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (NRF-2016R1A5A1010148) This work was also supported by the Incheon National University Research Grant in 2016.

Publisher Copyright:
© 2019 The Korean Society of Industrial and Engineering Chemistry

Keywords

1-tetradecanol
Droplet-based microfluidics
IR780
Microparticles
NIR light-triggered drug release
Phase change material

ASJC Scopus subject areas

General Chemical Engineering

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10.1016/j.jiec.2019.06.047

Cite this

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title = "Microfluidic fabrication of fatty alcohol-based microparticles for NIR light-triggered drug release",

abstract = "The development of photo-triggered drug delivery system is promising for the temporal and spatial control of drug release. However, most of the progress in photothermal drug delivery has been focused on nanosized particles which can be removed from the injected sites by exocytosis. In this study, injectable and implantable near-infrared (NIR) light-responsive microparticles are fabricated using droplet-based microfluidics. The particles are composed of 1-tetradecanol, as a class of non-toxic phase change material, and IR780, as a NIR-absorbing photothermal agent. Doxorubicin, an anticancer drug, is encapsulated in the particles to obtain NIR light-responsive anticancer drug carriers. The photothermal response of IR780 to NIR irradiation facilitates the release of the encapsulated drug through the melting of 1-tetradecanol and demonstrates the NIR light-responsive drug release. This study shows that IR780-encapsulated 1-tetradecanol microparticles fabricated by droplet-based microfluidics have great potential as injectable and implantable drug carriers featuring NIR light-sensitive drug release.",

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note = "Funding Information: This work was supported by the Engineering Research Center of Excellence Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning ( NRF-2016R1A5A1010148 ) This work was also supported by the Incheon National University Research Grant in 2016. Funding Information: This work was supported by the Engineering Research Center of Excellence Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (NRF-2016R1A5A1010148) This work was also supported by the Incheon National University Research Grant in 2016. Publisher Copyright: {\textcopyright} 2019 The Korean Society of Industrial and Engineering Chemistry",

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Microfluidic fabrication of fatty alcohol-based microparticles for NIR light-triggered drug release

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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