Abstract
Melanoma-derived exosomes have been known to play a significant role in the formation of tumor environment by initiating angiogenic processes and triggering metastatic evolution [1]. Recent studies have reported that the melanoma-derived exosomes triggered endothelial to mesenchymal transition (EndMT); this cellular transition induced the differentiation of endothelial cells to cancer-associated fibroblasts (CAFs) to remodel extracellular matrix (ECM) and increased the expression level of transforming growth factor beta (TGF-β) [2, 3]. However, an enabling tool in vitro is yet to be developed in order to investigate how cancer-derived exosomes induce the EndMT and cause the differentiation of endothelial cells to the CAFs. Here we suggest an in vitro microfluidic model that allows for monitoring a synergetic effect of both interstitial flow and the melanoma-derived exosomes on the EndMT.
| Original language | English |
|---|---|
| Title of host publication | MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 105-107 |
| Number of pages | 3 |
| ISBN (Electronic) | 9780979806483 |
| Publication status | Published - 2015 |
| Event | 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 - Gyeongju, Korea, Republic of Duration: 2015 Oct 25 → 2015 Oct 29 |
Other
| Other | 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 |
|---|---|
| Country/Territory | Korea, Republic of |
| City | Gyeongju |
| Period | 15/10/25 → 15/10/29 |
Keywords
- CAFs
- EndMT
- Exosome
- Interstitial flow
- Melanoma
- Microfluidic model
ASJC Scopus subject areas
- Control and Systems Engineering
