Microfluidic platforms for the study of cancer metastasis

Juan Lin Ng, Yoojin Shin, Seok Chung

    Research output: Contribution to journalReview articlepeer-review

    13 Citations (Scopus)

    Abstract

    Metastases many a time leave cancer patients untreatable and are one of the leading causes of death worldwide. Microfluidic platforms are arguably the most suitable for the study of cancer metastasis given its ability to mimic in vivo microenvironment of cancer tumor by manipulating its mechanical properties. This review discusses some applications of microfluidic platforms and their advantages for cancer biology and pathology. Studies of cancer metastasis conducted on its compositional steps enable us to elucidate elementary mechanisms through disease modeling. From that, communication and interaction of cancer cells, cellular metabolism related issues, and ultimately cancer drug discovery and delivery are manipulated on microfluidic platforms.

    Original languageEnglish
    Pages (from-to)72-77
    Number of pages6
    JournalBiomedical Engineering Letters
    Volume2
    Issue number2
    DOIs
    Publication statusPublished - 2012 Jun

    Keywords

    • Cancer metastasis
    • Microenvironment
    • Microfluidics

    ASJC Scopus subject areas

    • Biomedical Engineering

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