TY - JOUR
T1 - Microfluidic Reconstitution of Tumor Microenvironment for Nanomedical Applications
AU - Oh, Hyun Jeong
AU - Kim, Jaehoon
AU - Kim, Hyunho
AU - Choi, Nakwon
AU - Chung, Seok
N1 - Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (2020R1A2B5B03002005 and 2020R1C1C1011255). N.W.C. was supported by the KIST Institutional Program (Project nos. 2E30080 and 2E30180).
Publisher Copyright:
© 2021 Wiley-VCH GmbH
PY - 2021/5/5
Y1 - 2021/5/5
N2 - Nanoparticles have an extensive range of diagnostic and therapeutic applications in cancer treatment. However, their current clinical translation is slow, mainly due to the failure to develop preclinical evaluation techniques that can draw similar conclusions to clinical outcomes by adequately mimicking nanoparticle behavior in complicated tumor microenvironments (TMEs). Microfluidic methods offer significant advantages over conventional in vitro methods to resolve these challenges by recapitulating physiological cues of the TME such as the extracellular matrix, shear stress, interstitial flow, soluble factors, oxygen, and nutrient gradients. The methods are capable of de-coupling microenvironmental features, spatiotemporal controlling of experimental sequences, and high throughput readouts in situ. This progress report highlights the recent achievements of microfluidic models to reconstitute the physiological microenvironment, especially for nanomedical tools for cancer treatment.
AB - Nanoparticles have an extensive range of diagnostic and therapeutic applications in cancer treatment. However, their current clinical translation is slow, mainly due to the failure to develop preclinical evaluation techniques that can draw similar conclusions to clinical outcomes by adequately mimicking nanoparticle behavior in complicated tumor microenvironments (TMEs). Microfluidic methods offer significant advantages over conventional in vitro methods to resolve these challenges by recapitulating physiological cues of the TME such as the extracellular matrix, shear stress, interstitial flow, soluble factors, oxygen, and nutrient gradients. The methods are capable of de-coupling microenvironmental features, spatiotemporal controlling of experimental sequences, and high throughput readouts in situ. This progress report highlights the recent achievements of microfluidic models to reconstitute the physiological microenvironment, especially for nanomedical tools for cancer treatment.
KW - drug screening
KW - in vitro tumor models
KW - microfluidics
KW - nanomedicine
KW - tumor microenvironments
UR - http://www.scopus.com/inward/record.url?scp=85101053272&partnerID=8YFLogxK
U2 - 10.1002/adhm.202002122
DO - 10.1002/adhm.202002122
M3 - Review article
C2 - 33576178
AN - SCOPUS:85101053272
SN - 2192-2640
VL - 10
JO - Advanced Healthcare Materials
JF - Advanced Healthcare Materials
IS - 9
M1 - 2002122
ER -