Microfluidic study on ECM-dependent three dimensional morphogenesis of breast adenocarcinoma cells

Yoojin Shin; Sewoon Han; Hyunju Kim; Jae Hong Kim; Roger D. Kamm; Seok Chung

Microfluidic study on ECM-dependent three dimensional morphogenesis of breast adenocarcinoma cells

Yoojin Shin, Sewoon Han, Hyunju Kim, Jae Hong Kim, Roger D. Kamm, Seok Chung

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

When cancer cells move from original site to other parts of body by dissemination throughout blood vessel and lymphatic vessel, it is termed cancer metastasis. Cancer metastasis is complex and three-dimensional(3D) process integrated with various oncogenes, growth factors and interactions with stroma (stromal cells and surrounding ECM)[1]. In this paper, we have focused on the interaction between 3D ECM microenvironment and cancer cells by introducing various types of hydrogel in microfluidic system. Cancer cells showed various morphologies while invading into various types of ECM.

Original language	English
Title of host publication	15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Pages	353-355
Number of pages	3
Publication status	Published - 2011
Event	15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, United States Duration: 2011 Oct 2 → 2011 Oct 6

Publication series

Name	15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Volume	1

Other

Other	15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Country/Territory	United States
City	Seattle, WA
Period	11/10/2 → 11/10/6

Keywords

Cancer metastasis
Extracelluar Matrix (ECM)
Microfluidics
Three-dimensional migration

ASJC Scopus subject areas

Control and Systems Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

Shin, Y., Han, S., Kim, H., Kim, J. H., Kamm, R. D., & Chung, S. (2011). Microfluidic study on ECM-dependent three dimensional morphogenesis of breast adenocarcinoma cells. In 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 (pp. 353-355). (15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011; Vol. 1).

Microfluidic study on ECM-dependent three dimensional morphogenesis of breast adenocarcinoma cells. / Shin, Yoojin; Han, Sewoon; Kim, Hyunju et al.
15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. 2011. p. 353-355 (15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011; Vol. 1).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Shin, Y, Han, S, Kim, H, Kim, JH, Kamm, RD & Chung, S 2011, Microfluidic study on ECM-dependent three dimensional morphogenesis of breast adenocarcinoma cells. in 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011, vol. 1, pp. 353-355, 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011, Seattle, WA, United States, 11/10/2.

Shin Y, Han S, Kim H, Kim JH, Kamm RD, Chung S. Microfluidic study on ECM-dependent three dimensional morphogenesis of breast adenocarcinoma cells. In 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. 2011. p. 353-355. (15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011).

Shin, Yoojin ; Han, Sewoon ; Kim, Hyunju et al. / Microfluidic study on ECM-dependent three dimensional morphogenesis of breast adenocarcinoma cells. 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. 2011. pp. 353-355 (15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011).

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title = "Microfluidic study on ECM-dependent three dimensional morphogenesis of breast adenocarcinoma cells",

abstract = "When cancer cells move from original site to other parts of body by dissemination throughout blood vessel and lymphatic vessel, it is termed cancer metastasis. Cancer metastasis is complex and three-dimensional(3D) process integrated with various oncogenes, growth factors and interactions with stroma (stromal cells and surrounding ECM)[1]. In this paper, we have focused on the interaction between 3D ECM microenvironment and cancer cells by introducing various types of hydrogel in microfluidic system. Cancer cells showed various morphologies while invading into various types of ECM.",

keywords = "Cancer metastasis, Extracelluar Matrix (ECM), Microfluidics, Three-dimensional migration",

author = "Yoojin Shin and Sewoon Han and Hyunju Kim and Kim, {Jae Hong} and Kamm, {Roger D.} and Seok Chung",

year = "2011",

language = "English",

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series = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011",

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AU - Chung, Seok

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AB - When cancer cells move from original site to other parts of body by dissemination throughout blood vessel and lymphatic vessel, it is termed cancer metastasis. Cancer metastasis is complex and three-dimensional(3D) process integrated with various oncogenes, growth factors and interactions with stroma (stromal cells and surrounding ECM)[1]. In this paper, we have focused on the interaction between 3D ECM microenvironment and cancer cells by introducing various types of hydrogel in microfluidic system. Cancer cells showed various morphologies while invading into various types of ECM.

KW - Cancer metastasis

KW - Extracelluar Matrix (ECM)

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KW - Three-dimensional migration

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M3 - Conference contribution

AN - SCOPUS:84883767406

SN - 9781618395955

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EP - 355

BT - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011

T2 - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011

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ER -

Microfluidic study on ECM-dependent three dimensional morphogenesis of breast adenocarcinoma cells

Abstract

Publication series

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Keywords

ASJC Scopus subject areas

UN SDGs

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