Microfluidic Tracking of the Growth of Polymeric Vesicles in Hydrodynamic Flow

Xuan Don Nguyen; Dong Hyeok Park; Hyun Jong Paik; Hyeong Jin Jeon; June Huh; Jeung Sang Go

doi:10.1021/acsapm.0c01089

Microfluidic Tracking of the Growth of Polymeric Vesicles in Hydrodynamic Flow

Xuan Don Nguyen, Dong Hyeok Park, Hyun Jong Paik, Hyeong Jin Jeon, June Huh, Jeung Sang Go

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Polymeric vesicles (PVs) have proven to be a promising container for various agents because of the benefit of core-shell structures. The formation mechanism of PVs has been investigated in the hydrostatic media numerically and experimentally. However, it has been hardly reported in the hydrodynamic media of the microfluidic channel. This paper provides the visual evidence of the hydrodynamic formation mechanism of polystyrene-block-poly(ethylene glycol) vesicles. The PVs were prepared in a multiple lamination flow formed with a double flow-focusing microchannel (DFFM). To visualize the formation mechanism, the PV synthesis at each stage was characterized by scanning electron microscopy (SEM) taken along the microchannel length. Time-evolution of PV structure reveals that the formation of the PVs undergoes three distinctive morphological intermediates (micelles, disklike micelles, and semivesicles) before eventually reaching PVs, which can be tracked not only along the flow direction but also in its transverse direction. This mechanistic study for PV formation via microfluidic self-assembly provides an essential guideline for fabricating PVs with programmable morphologies that can be used in a variety of applications.

Original language	English
Pages (from-to)	5845-5850
Number of pages	6
Journal	ACS Applied Polymer Materials
Volume	2
Issue number	12
DOIs	https://doi.org/10.1021/acsapm.0c01089
Publication status	Published - 2020 Dec 11

Bibliographical note

Funding Information:
This work was financially supported by the National Research Foundation of Korea (NRF) grant funded by the Korea Government (MSIP) (Nos. 2017R1A2B2006264 and 2018M3D1A1058536).

Funding Information:
The authors would like to thank the National Research Foundation of Korea (NRF) and the Korean Government (MSIP) for supporting funds for this paper. J.H. thanks Creative Materials Discovery Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (2018M3D1A1058536).

Publisher Copyright:
© 2020 American Chemical Society

Keywords

double flow-focusing microchannel
microfluidic formation
multiple lamination flow
polymeric vesicles
shock freezing

ASJC Scopus subject areas

Polymers and Plastics
Process Chemistry and Technology
Organic Chemistry

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10.1021/acsapm.0c01089

Cite this

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title = "Microfluidic Tracking of the Growth of Polymeric Vesicles in Hydrodynamic Flow",

abstract = "Polymeric vesicles (PVs) have proven to be a promising container for various agents because of the benefit of core-shell structures. The formation mechanism of PVs has been investigated in the hydrostatic media numerically and experimentally. However, it has been hardly reported in the hydrodynamic media of the microfluidic channel. This paper provides the visual evidence of the hydrodynamic formation mechanism of polystyrene-block-poly(ethylene glycol) vesicles. The PVs were prepared in a multiple lamination flow formed with a double flow-focusing microchannel (DFFM). To visualize the formation mechanism, the PV synthesis at each stage was characterized by scanning electron microscopy (SEM) taken along the microchannel length. Time-evolution of PV structure reveals that the formation of the PVs undergoes three distinctive morphological intermediates (micelles, disklike micelles, and semivesicles) before eventually reaching PVs, which can be tracked not only along the flow direction but also in its transverse direction. This mechanistic study for PV formation via microfluidic self-assembly provides an essential guideline for fabricating PVs with programmable morphologies that can be used in a variety of applications. ",

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author = "Nguyen, \{Xuan Don\} and Park, \{Dong Hyeok\} and Paik, \{Hyun Jong\} and Jeon, \{Hyeong Jin\} and June Huh and Go, \{Jeung Sang\}",

note = "Funding Information: This work was financially supported by the National Research Foundation of Korea (NRF) grant funded by the Korea Government (MSIP) (Nos. 2017R1A2B2006264 and 2018M3D1A1058536). Funding Information: The authors would like to thank the National Research Foundation of Korea (NRF) and the Korean Government (MSIP) for supporting funds for this paper. J.H. thanks Creative Materials Discovery Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (2018M3D1A1058536). Publisher Copyright: {\textcopyright} 2020 American Chemical Society",

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AU - Go, Jeung Sang

N1 - Funding Information: This work was financially supported by the National Research Foundation of Korea (NRF) grant funded by the Korea Government (MSIP) (Nos. 2017R1A2B2006264 and 2018M3D1A1058536). Funding Information: The authors would like to thank the National Research Foundation of Korea (NRF) and the Korean Government (MSIP) for supporting funds for this paper. J.H. thanks Creative Materials Discovery Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (2018M3D1A1058536). Publisher Copyright: © 2020 American Chemical Society

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N2 - Polymeric vesicles (PVs) have proven to be a promising container for various agents because of the benefit of core-shell structures. The formation mechanism of PVs has been investigated in the hydrostatic media numerically and experimentally. However, it has been hardly reported in the hydrodynamic media of the microfluidic channel. This paper provides the visual evidence of the hydrodynamic formation mechanism of polystyrene-block-poly(ethylene glycol) vesicles. The PVs were prepared in a multiple lamination flow formed with a double flow-focusing microchannel (DFFM). To visualize the formation mechanism, the PV synthesis at each stage was characterized by scanning electron microscopy (SEM) taken along the microchannel length. Time-evolution of PV structure reveals that the formation of the PVs undergoes three distinctive morphological intermediates (micelles, disklike micelles, and semivesicles) before eventually reaching PVs, which can be tracked not only along the flow direction but also in its transverse direction. This mechanistic study for PV formation via microfluidic self-assembly provides an essential guideline for fabricating PVs with programmable morphologies that can be used in a variety of applications.

AB - Polymeric vesicles (PVs) have proven to be a promising container for various agents because of the benefit of core-shell structures. The formation mechanism of PVs has been investigated in the hydrostatic media numerically and experimentally. However, it has been hardly reported in the hydrodynamic media of the microfluidic channel. This paper provides the visual evidence of the hydrodynamic formation mechanism of polystyrene-block-poly(ethylene glycol) vesicles. The PVs were prepared in a multiple lamination flow formed with a double flow-focusing microchannel (DFFM). To visualize the formation mechanism, the PV synthesis at each stage was characterized by scanning electron microscopy (SEM) taken along the microchannel length. Time-evolution of PV structure reveals that the formation of the PVs undergoes three distinctive morphological intermediates (micelles, disklike micelles, and semivesicles) before eventually reaching PVs, which can be tracked not only along the flow direction but also in its transverse direction. This mechanistic study for PV formation via microfluidic self-assembly provides an essential guideline for fabricating PVs with programmable morphologies that can be used in a variety of applications.

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Microfluidic Tracking of the Growth of Polymeric Vesicles in Hydrodynamic Flow

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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