Micromechanical observation of the kinetics of biomolecular interactions

Taeyun Kwon, Kilho Eom, Jinsung Park, Dae Sung Yoon, Hong Lim Lee, Tae Song Kim

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)


Resonant microcantilevers have recently enabled the label-free detection of biomolecules. Here, we observed the kinetics of biomolecular interactions such as antigen-antibody interactions and/or DNA hybridization based on a resonant frequency shift, obeying Langmuir kinetics, measured in a buffer solution. It is shown that the kinetics of DNA adsorptions on the surface is governed by intermolecular interactions between adsorbed DNA molecules. It is also shown that the kinetics of DNA hybridization is determined by the intermolecular interaction. It is implied that resonant microcantilever in buffer solution may allow for gaining insights into the kinetics of various molecular interactions.

Original languageEnglish
Article number173901
JournalApplied Physics Letters
Issue number17
Publication statusPublished - 2008
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by Intelligent Microsystem Center sponsored by Korea Ministry of Science and Technology as a part of the 21st Century’s Frontier R&D project (Grant No. MS-01-133-01). First two authors equally contributed to this work.

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)


Dive into the research topics of 'Micromechanical observation of the kinetics of biomolecular interactions'. Together they form a unique fingerprint.

Cite this