Microplatforms for Gradient Field Generation of Various Properties and Biological Applications

Sung Hwan Kim, Gi Hun Lee, Joong Yull Park, Sang Hoon Lee

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)


Well-designed microfluidic platforms can be excellent tools to eliminate bottleneck problems or issues that have arisen in biological fields by providing unprecedented high-resolution control of mechanical and chemical microenvironments for cell culture. Among such microtechnologies, the precise generation of biochemical concentration gradients has been highly regarded in the biorelated scientific fields; even today, the principles and mechanisms for gradient generation continue to be refined, and the number of applications for this technique is growing. Here, we review the current status of the concentration gradient generation technologies achieved in various microplatforms and how they have been and will be applied to biological issues, particularly those that have arisen from cancer research, stem cell research, and tissue engineering. We also provide information about the advances and future challenges in the technological aspects of microscale concentration gradient generation.

Original languageEnglish
Pages (from-to)82-95
Number of pages14
JournalJournal of laboratory automation
Issue number2
Publication statusPublished - 2015 Apr 1


  • fabrication
  • lab-on-a-chip
  • microfluidics
  • microtechnology

ASJC Scopus subject areas

  • Computer Science Applications
  • Medical Laboratory Technology


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