TY - JOUR
T1 - MicroRNA-194-5p could serve as a diagnostic and prognostic biomarker in myelodysplastic syndromes
AU - Choi, Ji Seon
AU - Nam, Myung Hyun
AU - Yoon, Soo Young
AU - Kang, Seong Ho
N1 - Funding Information:
This study was supported by research funds from Chosun University (2014).
Publisher Copyright:
© 2015 Elsevier Ltd.
Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Trisomy 8 and trisomy 1q are the most frequent chromosomal abnormalities in Korean patients with myelodysplastic syndrome (MDS). MicroRNA (miRNA) deregulation is involved in the development of hematological malignancies, including MDS, and cancer-associated genomic regions are known to encode miRNAs. The aim of the present study was to investigate the involvement of miRNAs encoded by chromosomes 8 and 1q in MDS. For this, the expression of nine miRNAs encoded by chromosome 8 (miR-30b-5p, miR-30d-5p, miR-101-3p, miR-124-3p, miR-151a-5p, miR-320a, miR-486-5p, miR-596, and miR-875-5p) and three miRNAs encoded by chromosome 1q (miR-29c-3p, miR-194-5p, and miR-214-3p) was compared between 65 MDS patients and 11 controls. We found a significant upregulation of miR-194-5p (5.1-fold, P = 0.002) and miR-320a (2.94-fold, P = 0.016) in MDS patients compared with controls. The patients with low miR-194-5p expression showed a significantly decreased overall survival (P = 0.049). The areas under the miR-194-5p and miR-320a ROC curves were 0.797 (P = 0.002) and 0.729 (P = 0.016), respectively. Although these findings need to be validated in a larger patient population, our results indicate that miR-194-5p is a candidate diagnostic biomarker for MDS and that low miR-194-5p expression could be associated with poor overall survival for MDS patients.
AB - Trisomy 8 and trisomy 1q are the most frequent chromosomal abnormalities in Korean patients with myelodysplastic syndrome (MDS). MicroRNA (miRNA) deregulation is involved in the development of hematological malignancies, including MDS, and cancer-associated genomic regions are known to encode miRNAs. The aim of the present study was to investigate the involvement of miRNAs encoded by chromosomes 8 and 1q in MDS. For this, the expression of nine miRNAs encoded by chromosome 8 (miR-30b-5p, miR-30d-5p, miR-101-3p, miR-124-3p, miR-151a-5p, miR-320a, miR-486-5p, miR-596, and miR-875-5p) and three miRNAs encoded by chromosome 1q (miR-29c-3p, miR-194-5p, and miR-214-3p) was compared between 65 MDS patients and 11 controls. We found a significant upregulation of miR-194-5p (5.1-fold, P = 0.002) and miR-320a (2.94-fold, P = 0.016) in MDS patients compared with controls. The patients with low miR-194-5p expression showed a significantly decreased overall survival (P = 0.049). The areas under the miR-194-5p and miR-320a ROC curves were 0.797 (P = 0.002) and 0.729 (P = 0.016), respectively. Although these findings need to be validated in a larger patient population, our results indicate that miR-194-5p is a candidate diagnostic biomarker for MDS and that low miR-194-5p expression could be associated with poor overall survival for MDS patients.
KW - Deregulation
KW - Diagnosis
KW - MDS
KW - MicroRNA
KW - Prognosis
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UR - http://www.scopus.com/inward/citedby.url?scp=84930377843&partnerID=8YFLogxK
U2 - 10.1016/j.leukres.2015.04.013
DO - 10.1016/j.leukres.2015.04.013
M3 - Article
C2 - 25975751
AN - SCOPUS:84930377843
SN - 0145-2126
VL - 39
SP - 763
EP - 768
JO - Leukemia Research
JF - Leukemia Research
IS - 7
ER -
