Microstructural connectivity is more related to cognition than conventional MRI in Parkinson's disease

Yang Hyun Lee; Wha Jin Lee; Seok Jong Chung; Han Soo Yoo; Jin Ho Jung; Kyoungwon Baik; Young H. Sohn; Joon Kyung Seong; Phil Hyu Lee

doi:10.3233/JPD-202312

Microstructural connectivity is more related to cognition than conventional MRI in Parkinson's disease

Yang Hyun Lee, Wha Jin Lee, Seok Jong Chung, Han Soo Yoo, Jin Ho Jung, Kyoungwon Baik, Young H. Sohn, Joon Kyung Seong, Phil Hyu Lee

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Background: The different effects of white matter hyperintensity (WMH) severity and WMH-associated microstructural connectivity on cognition in the early stages of Parkinson's disease (PD) have not been investigated. Objective: To investigate the differential effect of WMH severity and WMH-associated microstructural connectivity on cognition in early stages of PD. Methods: A total of 136 de novo PD patients were enrolled and divided into groups based on total WMH visual rating scores as follows: mild, moderate, and severe. Microstructural connectivity was measured using graph theoretical analysis according to WMH severity. Additionally, correlation coefficients between WMH-associated microstructural connectivity or WMH scores and cognitive performance were assessed. Results: Patients with severe WMHs demonstrated poorer performance in language function than those with moderate WMHs, and in frontal/executive and visual memory function than those with mild WMHs. Areas of microstructural connectivity were more extensive in patients with severe WMHs compared to those with mild and moderate WMHs, involving frontal and parieto-temporal regions. WMH-associated right fronto-temporo-parietal microstructural disintegration was correlated with cognitive dysfunction in attention, frontal/executive, and memory domains, whereas there was no correlation between WMH scores and any cognitive domains. Conclusion: These data suggest that disruption of microstructural networks by WMHs, rather than WMH burden itself, contributed more to cognitive impairment in PD.

Original language	English
Pages (from-to)	239-249
Number of pages	11
Journal	Journal of Parkinson's Disease
Volume	11
Issue number	1
DOIs	https://doi.org/10.3233/JPD-202312
Publication status	Published - 2021

Bibliographical note

Funding Information:
In conclusion, our findings demonstrated that microstructural network disruption by WMHs rather than the WMH burden itself, contributed more to cognitive impairment in patients with PD, especially in association with microstructural dysconnectivity in parieto-temporal areas. The current data suggest that individual diffusion metrics when investigating This work was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (NRF-2016R1A2A2A05920131). Phil Hyu Lee receives funding from NRF-2016R1A2A2A05920131. This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number : HI19C1132).

Publisher Copyright:
© 2021 - IOS Press. All rights reserved.

Keywords

Cognition
Diffusion tensor imaging
Microstructural connectivity
Parkinson's disease
White matter hyperintensities

ASJC Scopus subject areas

Clinical Neurology
Cellular and Molecular Neuroscience

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10.3233/JPD-202312

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title = "Microstructural connectivity is more related to cognition than conventional MRI in Parkinson's disease",

abstract = "Background: The different effects of white matter hyperintensity (WMH) severity and WMH-associated microstructural connectivity on cognition in the early stages of Parkinson's disease (PD) have not been investigated. Objective: To investigate the differential effect of WMH severity and WMH-associated microstructural connectivity on cognition in early stages of PD. Methods: A total of 136 de novo PD patients were enrolled and divided into groups based on total WMH visual rating scores as follows: mild, moderate, and severe. Microstructural connectivity was measured using graph theoretical analysis according to WMH severity. Additionally, correlation coefficients between WMH-associated microstructural connectivity or WMH scores and cognitive performance were assessed. Results: Patients with severe WMHs demonstrated poorer performance in language function than those with moderate WMHs, and in frontal/executive and visual memory function than those with mild WMHs. Areas of microstructural connectivity were more extensive in patients with severe WMHs compared to those with mild and moderate WMHs, involving frontal and parieto-temporal regions. WMH-associated right fronto-temporo-parietal microstructural disintegration was correlated with cognitive dysfunction in attention, frontal/executive, and memory domains, whereas there was no correlation between WMH scores and any cognitive domains. Conclusion: These data suggest that disruption of microstructural networks by WMHs, rather than WMH burden itself, contributed more to cognitive impairment in PD.",

keywords = "Cognition, Diffusion tensor imaging, Microstructural connectivity, Parkinson's disease, White matter hyperintensities",

author = "Lee, {Yang Hyun} and Lee, {Wha Jin} and Chung, {Seok Jong} and Yoo, {Han Soo} and Jung, {Jin Ho} and Kyoungwon Baik and Sohn, {Young H.} and Seong, {Joon Kyung} and Lee, {Phil Hyu}",

note = "Funding Information: In conclusion, our findings demonstrated that microstructural network disruption by WMHs rather than the WMH burden itself, contributed more to cognitive impairment in patients with PD, especially in association with microstructural dysconnectivity in parieto-temporal areas. The current data suggest that individual diffusion metrics when investigating This work was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (NRF-2016R1A2A2A05920131). Phil Hyu Lee receives funding from NRF-2016R1A2A2A05920131. This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number : HI19C1132). Publisher Copyright: {\textcopyright} 2021 - IOS Press. All rights reserved.",

year = "2021",

doi = "10.3233/JPD-202312",

language = "English",

volume = "11",

pages = "239--249",

journal = "Journal of Parkinson's Disease",

issn = "1877-7171",

publisher = "SAGE Publications Ltd",

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TY - JOUR

T1 - Microstructural connectivity is more related to cognition than conventional MRI in Parkinson's disease

AU - Lee, Yang Hyun

AU - Lee, Wha Jin

AU - Chung, Seok Jong

AU - Yoo, Han Soo

AU - Jung, Jin Ho

AU - Baik, Kyoungwon

AU - Sohn, Young H.

AU - Seong, Joon Kyung

AU - Lee, Phil Hyu

N1 - Funding Information: In conclusion, our findings demonstrated that microstructural network disruption by WMHs rather than the WMH burden itself, contributed more to cognitive impairment in patients with PD, especially in association with microstructural dysconnectivity in parieto-temporal areas. The current data suggest that individual diffusion metrics when investigating This work was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (NRF-2016R1A2A2A05920131). Phil Hyu Lee receives funding from NRF-2016R1A2A2A05920131. This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number : HI19C1132). Publisher Copyright: © 2021 - IOS Press. All rights reserved.

PY - 2021

Y1 - 2021

N2 - Background: The different effects of white matter hyperintensity (WMH) severity and WMH-associated microstructural connectivity on cognition in the early stages of Parkinson's disease (PD) have not been investigated. Objective: To investigate the differential effect of WMH severity and WMH-associated microstructural connectivity on cognition in early stages of PD. Methods: A total of 136 de novo PD patients were enrolled and divided into groups based on total WMH visual rating scores as follows: mild, moderate, and severe. Microstructural connectivity was measured using graph theoretical analysis according to WMH severity. Additionally, correlation coefficients between WMH-associated microstructural connectivity or WMH scores and cognitive performance were assessed. Results: Patients with severe WMHs demonstrated poorer performance in language function than those with moderate WMHs, and in frontal/executive and visual memory function than those with mild WMHs. Areas of microstructural connectivity were more extensive in patients with severe WMHs compared to those with mild and moderate WMHs, involving frontal and parieto-temporal regions. WMH-associated right fronto-temporo-parietal microstructural disintegration was correlated with cognitive dysfunction in attention, frontal/executive, and memory domains, whereas there was no correlation between WMH scores and any cognitive domains. Conclusion: These data suggest that disruption of microstructural networks by WMHs, rather than WMH burden itself, contributed more to cognitive impairment in PD.

AB - Background: The different effects of white matter hyperintensity (WMH) severity and WMH-associated microstructural connectivity on cognition in the early stages of Parkinson's disease (PD) have not been investigated. Objective: To investigate the differential effect of WMH severity and WMH-associated microstructural connectivity on cognition in early stages of PD. Methods: A total of 136 de novo PD patients were enrolled and divided into groups based on total WMH visual rating scores as follows: mild, moderate, and severe. Microstructural connectivity was measured using graph theoretical analysis according to WMH severity. Additionally, correlation coefficients between WMH-associated microstructural connectivity or WMH scores and cognitive performance were assessed. Results: Patients with severe WMHs demonstrated poorer performance in language function than those with moderate WMHs, and in frontal/executive and visual memory function than those with mild WMHs. Areas of microstructural connectivity were more extensive in patients with severe WMHs compared to those with mild and moderate WMHs, involving frontal and parieto-temporal regions. WMH-associated right fronto-temporo-parietal microstructural disintegration was correlated with cognitive dysfunction in attention, frontal/executive, and memory domains, whereas there was no correlation between WMH scores and any cognitive domains. Conclusion: These data suggest that disruption of microstructural networks by WMHs, rather than WMH burden itself, contributed more to cognitive impairment in PD.

KW - Cognition

KW - Diffusion tensor imaging

KW - Microstructural connectivity

KW - Parkinson's disease

KW - White matter hyperintensities

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DO - 10.3233/JPD-202312

M3 - Article

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AN - SCOPUS:85100545516

SN - 1877-7171

VL - 11

SP - 239

EP - 249

JO - Journal of Parkinson's Disease

JF - Journal of Parkinson's Disease

IS - 1

ER -

Microstructural connectivity is more related to cognition than conventional MRI in Parkinson's disease

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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