Microstructure and Magnetic Properties of LaSrMnO Nanoparticles and Their Application to Cardiac Immunoassay

Woo Seung Ham; Min Kyung Kim; Ji Seok Gim; Ji Sung Lee; Jun Hua Wu; Kyu Back Lee; Young Keun Kim

doi:10.1109/TMAG.2015.2438021

Microstructure and Magnetic Properties of LaSrMnO Nanoparticles and Their Application to Cardiac Immunoassay

Woo Seung Ham, Min Kyung Kim, Ji Seok Gim, Ji Sung Lee, Jun Hua Wu, Kyu Back Lee, Young Keun Kim

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Though enzyme-linked immunosorbent assay is widely used in laboratory medicine, it has limitations due to interactions between enzymes and secondary antibodies. Here, we propose a new cardiac assay scheme for detecting troponin I antigens based on La_(1-x)Sr_xMnO₃ (x=0.10, 0.15, and 0.25) nanoparticles (NPs). These NPs are synthesized via a modified polyol process followed by heat treatment. An increase in x induces changes in crystal structure and increases both Curie temperature and saturation magnetization. The NPs with x=0.15 exhibit a Curie temperature close to the human body temperature. The limit of detection is found to be 0.78 ng/mL. We also confirm that LaSrMnO NPs are reusable after heating the assay plate.

Original language	English
Article number	7113860
Journal	IEEE Transactions on Magnetics
Volume	51
Issue number	11
DOIs	https://doi.org/10.1109/TMAG.2015.2438021
Publication status	Published - 2015 Nov 1

Bibliographical note

Publisher Copyright:
© 2015 IEEE.

Keywords

Cardiac troponin I (cTnI)
Curie temperature
LaSrMnO nanoparticles (NPs)
immunoassay

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Electrical and Electronic Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1109/TMAG.2015.2438021

Cite this

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abstract = "Though enzyme-linked immunosorbent assay is widely used in laboratory medicine, it has limitations due to interactions between enzymes and secondary antibodies. Here, we propose a new cardiac assay scheme for detecting troponin I antigens based on La(1-x)SrxMnO3 (x=0.10, 0.15, and 0.25) nanoparticles (NPs). These NPs are synthesized via a modified polyol process followed by heat treatment. An increase in x induces changes in crystal structure and increases both Curie temperature and saturation magnetization. The NPs with x=0.15 exhibit a Curie temperature close to the human body temperature. The limit of detection is found to be 0.78 ng/mL. We also confirm that LaSrMnO NPs are reusable after heating the assay plate.",

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AU - Ham, Woo Seung

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AU - Lee, Ji Sung

AU - Wu, Jun Hua

AU - Lee, Kyu Back

AU - Kim, Young Keun

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AB - Though enzyme-linked immunosorbent assay is widely used in laboratory medicine, it has limitations due to interactions between enzymes and secondary antibodies. Here, we propose a new cardiac assay scheme for detecting troponin I antigens based on La(1-x)SrxMnO3 (x=0.10, 0.15, and 0.25) nanoparticles (NPs). These NPs are synthesized via a modified polyol process followed by heat treatment. An increase in x induces changes in crystal structure and increases both Curie temperature and saturation magnetization. The NPs with x=0.15 exhibit a Curie temperature close to the human body temperature. The limit of detection is found to be 0.78 ng/mL. We also confirm that LaSrMnO NPs are reusable after heating the assay plate.

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Microstructure and Magnetic Properties of LaSrMnO Nanoparticles and Their Application to Cardiac Immunoassay

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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