Microstructure and Magnetic Properties of LaSrMnO Nanoparticles and Their Application to Cardiac Immunoassay

Woo Seung Ham; Min Kyung Kim; Ji Seok Gim; Ji Sung Lee; Jun Hua Wu; Kyu Back Lee; Young Keun Kim

doi:10.1109/TMAG.2015.2438021

Microstructure and Magnetic Properties of LaSrMnO Nanoparticles and Their Application to Cardiac Immunoassay

Woo Seung Ham
, Min Kyung Kim
, Ji Seok Gim
, Ji Sung Lee
, Jun Hua Wu
, Kyu Back Lee
, Young Keun Kim^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Though enzyme-linked immunosorbent assay is widely used in laboratory medicine, it has limitations due to interactions between enzymes and secondary antibodies. Here, we propose a new cardiac assay scheme for detecting troponin I antigens based on La_(1-x)Sr_xMnO₃ (x=0.10, 0.15, and 0.25) nanoparticles (NPs). These NPs are synthesized via a modified polyol process followed by heat treatment. An increase in x induces changes in crystal structure and increases both Curie temperature and saturation magnetization. The NPs with x=0.15 exhibit a Curie temperature close to the human body temperature. The limit of detection is found to be 0.78 ng/mL. We also confirm that LaSrMnO NPs are reusable after heating the assay plate.

Original language	English
Article number	7113860
Journal	IEEE Transactions on Magnetics
Volume	51
Issue number	11
DOIs	https://doi.org/10.1109/TMAG.2015.2438021
Publication status	Published - 2015 Nov 1

Bibliographical note

Publisher Copyright:
© 2015 IEEE.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cardiac troponin I (cTnI)
Curie temperature
LaSrMnO nanoparticles (NPs)
immunoassay

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Electrical and Electronic Engineering

Access to Document

10.1109/TMAG.2015.2438021

Cite this

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title = "Microstructure and Magnetic Properties of LaSrMnO Nanoparticles and Their Application to Cardiac Immunoassay",

abstract = "Though enzyme-linked immunosorbent assay is widely used in laboratory medicine, it has limitations due to interactions between enzymes and secondary antibodies. Here, we propose a new cardiac assay scheme for detecting troponin I antigens based on La(1-x)SrxMnO3 (x=0.10, 0.15, and 0.25) nanoparticles (NPs). These NPs are synthesized via a modified polyol process followed by heat treatment. An increase in x induces changes in crystal structure and increases both Curie temperature and saturation magnetization. The NPs with x=0.15 exhibit a Curie temperature close to the human body temperature. The limit of detection is found to be 0.78 ng/mL. We also confirm that LaSrMnO NPs are reusable after heating the assay plate.",

keywords = "Cardiac troponin I (cTnI), Curie temperature, LaSrMnO nanoparticles (NPs), immunoassay",

author = "Ham, \{Woo Seung\} and Kim, \{Min Kyung\} and Gim, \{Ji Seok\} and Lee, \{Ji Sung\} and Wu, \{Jun Hua\} and Lee, \{Kyu Back\} and Kim, \{Young Keun\}",

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doi = "10.1109/TMAG.2015.2438021",

language = "English",

volume = "51",

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T1 - Microstructure and Magnetic Properties of LaSrMnO Nanoparticles and Their Application to Cardiac Immunoassay

AU - Ham, Woo Seung

AU - Kim, Min Kyung

AU - Gim, Ji Seok

AU - Lee, Ji Sung

AU - Wu, Jun Hua

AU - Lee, Kyu Back

AU - Kim, Young Keun

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Though enzyme-linked immunosorbent assay is widely used in laboratory medicine, it has limitations due to interactions between enzymes and secondary antibodies. Here, we propose a new cardiac assay scheme for detecting troponin I antigens based on La(1-x)SrxMnO3 (x=0.10, 0.15, and 0.25) nanoparticles (NPs). These NPs are synthesized via a modified polyol process followed by heat treatment. An increase in x induces changes in crystal structure and increases both Curie temperature and saturation magnetization. The NPs with x=0.15 exhibit a Curie temperature close to the human body temperature. The limit of detection is found to be 0.78 ng/mL. We also confirm that LaSrMnO NPs are reusable after heating the assay plate.

AB - Though enzyme-linked immunosorbent assay is widely used in laboratory medicine, it has limitations due to interactions between enzymes and secondary antibodies. Here, we propose a new cardiac assay scheme for detecting troponin I antigens based on La(1-x)SrxMnO3 (x=0.10, 0.15, and 0.25) nanoparticles (NPs). These NPs are synthesized via a modified polyol process followed by heat treatment. An increase in x induces changes in crystal structure and increases both Curie temperature and saturation magnetization. The NPs with x=0.15 exhibit a Curie temperature close to the human body temperature. The limit of detection is found to be 0.78 ng/mL. We also confirm that LaSrMnO NPs are reusable after heating the assay plate.

KW - Cardiac troponin I (cTnI)

KW - Curie temperature

KW - LaSrMnO nanoparticles (NPs)

KW - immunoassay

UR - https://www.scopus.com/pages/publications/84946238465

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DO - 10.1109/TMAG.2015.2438021

M3 - Article

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JO - IEEE Transactions on Magnetics

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Microstructure and Magnetic Properties of LaSrMnO Nanoparticles and Their Application to Cardiac Immunoassay

Abstract

Bibliographical note

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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