Microvascular integrity as a predictor of left ventricular remodeling after acute anterior wall myocardial infarction

Wan Joo Shim, Eun Mi Lee, Gyo Seung Hwang, Jeung Cheon Ahn, Woo Hyuk Song, Do Sun Lim, Chang Gyu Park, Young Hoon Kim, Mong Seog Seo, Dong Joo Oh, Young Moo Ro

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2 Citations (Scopus)


The purpose of this study was to investigate the relation of microvascular integrity and ventricular remodeling after acute myocardial infarction. Twenty-six patients with first acute anterior myocardial infarction were studied before discharge with myocardial contrast echocardiography (MCE). Opacification index (OI) and wall motion index were calculated in the left anterior descending artery territory and left ventricular diastolic volume was measured at baseline and during a 9-month follow-up. In total 26 patients, the regional wall motion improved but the left ventricular volume and global function was not changed significantly at follow-up. When the patients were divided into 3 groups according to opacification index (≥0.75, 0.5-0.75, ≤0.5) at baseline, functional recovery was not observed and significant left ventricular dilatation was developed in patients with ≤0.5 OI. Among the baseline echo-parameters such as ejection fraction, wall motion score, left ventricular volume and opacification index, the best predictor for long term left ventricular dilatation was the opacification index by multivariate analysis. In patients with acute anterior wall infarction the assessment of microvascular integrity by MCE at acute stage provides useful information regarding recovery of dysfunctional regional wall motion and ventricular remodeling.

Original languageEnglish
Pages (from-to)466-472
Number of pages7
JournalJournal of Korean medical science
Issue number5
Publication statusPublished - 1998 Oct


  • Echocardiography
  • Myocardial diseases
  • Myocardial infarction
  • Ventricular remodeling

ASJC Scopus subject areas

  • Medicine(all)


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