Microwave-assisted amination of 3-bromo-2-chloropyridine with various substituted aminoethanols

Jeong Geun Kim, Eun Hae Yang, Woo Sup Youn, Ji Won Choi, Deok Chan Ha, Jae Du Ha

    Research output: Contribution to journalArticlepeer-review

    7 Citations (Scopus)

    Abstract

    A simple method for microwave-assisted amination of 3-bromo-2-chloropyridine with various substituted aminoethanols is described. The reaction was carried out under microwave irradiation conditions (at 180 °C for 1-2 h) and the result was superior in terms of conversion and yield when compared to that of the corresponding conventional heating conditions.

    Original languageEnglish
    Pages (from-to)3886-3889
    Number of pages4
    JournalTetrahedron Letters
    Volume51
    Issue number30
    DOIs
    Publication statusPublished - 2010 Jul 28

    Bibliographical note

    Funding Information:
    We are grateful to the Korea Research Institute of Chemical Technology (KRICT) for financial support.

    Copyright:
    Copyright 2010 Elsevier B.V., All rights reserved.

    Keywords

    • 3-Bromo-2-chloropyridine
    • Aminoethanol
    • Microwave-assisted amination
    • Pyrido[1,4]oxazine

    ASJC Scopus subject areas

    • Biochemistry
    • Drug Discovery
    • Organic Chemistry

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