Abstract
A simple method for microwave-assisted amination of 3-bromo-2-chloropyridine with various substituted aminoethanols is described. The reaction was carried out under microwave irradiation conditions (at 180 °C for 1-2 h) and the result was superior in terms of conversion and yield when compared to that of the corresponding conventional heating conditions.
Original language | English |
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Pages (from-to) | 3886-3889 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 51 |
Issue number | 30 |
DOIs | |
Publication status | Published - 2010 Jul 28 |
Bibliographical note
Funding Information:We are grateful to the Korea Research Institute of Chemical Technology (KRICT) for financial support.
Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.
Keywords
- 3-Bromo-2-chloropyridine
- Aminoethanol
- Microwave-assisted amination
- Pyrido[1,4]oxazine
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry