A simple method for microwave-assisted amination of 3-bromo-2-chloropyridine with various substituted aminoethanols is described. The reaction was carried out under microwave irradiation conditions (at 180 °C for 1-2 h) and the result was superior in terms of conversion and yield when compared to that of the corresponding conventional heating conditions.
Bibliographical noteFunding Information:
We are grateful to the Korea Research Institute of Chemical Technology (KRICT) for financial support.
Copyright 2010 Elsevier B.V., All rights reserved.
- Microwave-assisted amination
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry