Microwave-assisted amination of 3-bromo-2-chloropyridine with various substituted aminoethanols

Jeong Geun Kim; Eun Hae Yang; Woo Sup Youn; Ji Won Choi; Deok Chan Ha; Jae Du Ha

doi:10.1016/j.tetlet.2010.05.021

Microwave-assisted amination of 3-bromo-2-chloropyridine with various substituted aminoethanols

Jeong Geun Kim, Eun Hae Yang, Woo Sup Youn, Ji Won Choi, Deok Chan Ha, Jae Du Ha

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

A simple method for microwave-assisted amination of 3-bromo-2-chloropyridine with various substituted aminoethanols is described. The reaction was carried out under microwave irradiation conditions (at 180 °C for 1-2 h) and the result was superior in terms of conversion and yield when compared to that of the corresponding conventional heating conditions.

Original language	English
Pages (from-to)	3886-3889
Number of pages	4
Journal	Tetrahedron Letters
Volume	51
Issue number	30
DOIs	https://doi.org/10.1016/j.tetlet.2010.05.021
Publication status	Published - 2010 Jul 28

Bibliographical note

Funding Information:
We are grateful to the Korea Research Institute of Chemical Technology (KRICT) for financial support.

Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.

Keywords

3-Bromo-2-chloropyridine
Aminoethanol
Microwave-assisted amination
Pyrido[1,4]oxazine

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2010.05.021

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abstract = "A simple method for microwave-assisted amination of 3-bromo-2-chloropyridine with various substituted aminoethanols is described. The reaction was carried out under microwave irradiation conditions (at 180 °C for 1-2 h) and the result was superior in terms of conversion and yield when compared to that of the corresponding conventional heating conditions.",

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AU - Kim, Jeong Geun

AU - Yang, Eun Hae

AU - Youn, Woo Sup

AU - Choi, Ji Won

AU - Ha, Deok Chan

AU - Ha, Jae Du

PY - 2010/7/28

Y1 - 2010/7/28

N2 - A simple method for microwave-assisted amination of 3-bromo-2-chloropyridine with various substituted aminoethanols is described. The reaction was carried out under microwave irradiation conditions (at 180 °C for 1-2 h) and the result was superior in terms of conversion and yield when compared to that of the corresponding conventional heating conditions.

AB - A simple method for microwave-assisted amination of 3-bromo-2-chloropyridine with various substituted aminoethanols is described. The reaction was carried out under microwave irradiation conditions (at 180 °C for 1-2 h) and the result was superior in terms of conversion and yield when compared to that of the corresponding conventional heating conditions.

KW - 3-Bromo-2-chloropyridine

KW - Aminoethanol

KW - Microwave-assisted amination

KW - Pyrido[1,4]oxazine

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JF - Tetrahedron Letters

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ER -

Microwave-assisted amination of 3-bromo-2-chloropyridine with various substituted aminoethanols

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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