Mitochondria and AMP-activated protein kinase-dependent mechanism of efferocytosis

Shaoning Jiang, Dae Won Park, William S. Stigler, Judy Creighton, Saranya Ravi, Victor Darley-Usmar, Jaroslaw W. Zmijewski

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)


Background: Billions of cells undergo apoptosis in the human body every day, and the removal of dying cells (efferocytosis) is essential for tissue homeostasis. Results: Energy demand during efferocytosis results in AMPK activation followed by enhancement of macrophage chemokinesis and efferocytosis. Conclusion: The AMPK pathway is intimately linked to cellular bioenergetics and efferocytosis. Significance: A novel mechanism of mitochondria and AMPK-dependent stimulation of efferocytosis is proposed.

Original languageEnglish
Pages (from-to)26013-26026
Number of pages14
JournalJournal of Biological Chemistry
Issue number36
Publication statusPublished - 2013 Sept 6
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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