Mitochondrial dysfunction and immune cell metabolism in sepsis

Dae Won Park, Jaroslaw W. Zmijewski

Research output: Contribution to journalReview articlepeer-review

32 Citations (Scopus)


Sepsis is a life threatening condition mediated by systemic infection, but also triggered by hemorrhage and trauma. These are significant causes of organ injury implicated in morbidity and mortality, as well as post-sepsis complications associated with dysfunction of innate and adaptive immunity. The role of cellular bioenergetics and loss of metabolic plasticity of immune cells is increasingly emerging in the pathogenesis of sepsis. This review describes mitochondrial biology and metabolic alterations of immune cells due to sepsis, as well as indicates plausible therapeutic opportunities.

Original languageEnglish
Pages (from-to)10-21
Number of pages12
JournalInfection and Chemotherapy
Issue number1
Publication statusPublished - 2017 Mar 1
Externally publishedYes

Bibliographical note

Funding Information:
Park, D.W. was supported by grants from Korea University (K1032201, K1613721) and JW Zmijewski was supported by National Institutes of Health Grant (HL107585).

Publisher Copyright:
© 2017 by The Korean Society of Infectious Diseases.


  • Immune cell
  • Metabolism
  • Mitochondria
  • Multi-organ failure
  • Sepsis

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)


Dive into the research topics of 'Mitochondrial dysfunction and immune cell metabolism in sepsis'. Together they form a unique fingerprint.

Cite this