Mitochondrial ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21WAF1/CIP1

Mi Jin Kim; Young A. Yoo; Hyung Jung Kim; Seongman Kang; Yong Geon Kim; Jun Suk Kim; Young Do Yoo

doi:10.1016/j.bbrc.2005.10.064

Mitochondrial ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21^WAF1/CIP1

Mi Jin Kim, Young A. Yoo, Hyung Jung Kim, Seongman Kang, Yong Geon Kim, Jun Suk Kim, Young Do Yoo

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Ribosomal proteins not only act as components of the translation apparatus but also regulate cell proliferation and apoptosis. A previous study reported that MRPL41 plays an important role in p53-dependent apoptosis. It also showed that MRPL41 arrests the cell cycle by stabilizing p27^Kip1 in the absence of p53. This study found that MRPL41 mediates the p21 ^WAF1/CIP1-mediated G1 arrest in response to serum starvation. The cells were released from serum starvation-induced G1 arrest via the siRNA-mediated blocking of MRPL41 expression. Overall, these results suggest that MRPL41 arrests the cell cycle by increasing the p21^WAF1/CIP1 and p27^Kip1 levels under the growth inhibitory conditions.

Original language	English
Pages (from-to)	1179-1184
Number of pages	6
Journal	Biochemical and biophysical research communications
Volume	338
Issue number	2
DOIs	https://doi.org/10.1016/j.bbrc.2005.10.064
Publication status	Published - 2005 Dec 16

Bibliographical note

Funding Information:
This research was supported by a grant from the Korean Ministry of Health and Welfare (HMP-02-PJ1-CH03-0001), by a grant from the National Nuclear R&D Program of MOST/KOSEF (M20513000082-05B0900-08200), and by a grant from the Molecular and Cellular BioDiscovery Research Program (M1-0311-00-0035) of MOST/KOSEF.

Keywords

Cell cycle
MRPL41
Serum starvation
p21
p27
p53

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1016/j.bbrc.2005.10.064

Cite this

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title = "Mitochondrial ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21WAF1/CIP1",

abstract = "Ribosomal proteins not only act as components of the translation apparatus but also regulate cell proliferation and apoptosis. A previous study reported that MRPL41 plays an important role in p53-dependent apoptosis. It also showed that MRPL41 arrests the cell cycle by stabilizing p27Kip1 in the absence of p53. This study found that MRPL41 mediates the p21 WAF1/CIP1-mediated G1 arrest in response to serum starvation. The cells were released from serum starvation-induced G1 arrest via the siRNA-mediated blocking of MRPL41 expression. Overall, these results suggest that MRPL41 arrests the cell cycle by increasing the p21WAF1/CIP1 and p27Kip1 levels under the growth inhibitory conditions.",

keywords = "Cell cycle, MRPL41, Serum starvation, p21, p27, p53",

author = "Kim, {Mi Jin} and Yoo, {Young A.} and Kim, {Hyung Jung} and Seongman Kang and Kim, {Yong Geon} and Kim, {Jun Suk} and Yoo, {Young Do}",

note = "Funding Information: This research was supported by a grant from the Korean Ministry of Health and Welfare (HMP-02-PJ1-CH03-0001), by a grant from the National Nuclear R&D Program of MOST/KOSEF (M20513000082-05B0900-08200), and by a grant from the Molecular and Cellular BioDiscovery Research Program (M1-0311-00-0035) of MOST/KOSEF.",

year = "2005",

month = dec,

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doi = "10.1016/j.bbrc.2005.10.064",

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AU - Kim, Mi Jin

AU - Yoo, Young A.

AU - Kim, Hyung Jung

AU - Kang, Seongman

AU - Kim, Yong Geon

AU - Kim, Jun Suk

AU - Yoo, Young Do

N1 - Funding Information: This research was supported by a grant from the Korean Ministry of Health and Welfare (HMP-02-PJ1-CH03-0001), by a grant from the National Nuclear R&D Program of MOST/KOSEF (M20513000082-05B0900-08200), and by a grant from the Molecular and Cellular BioDiscovery Research Program (M1-0311-00-0035) of MOST/KOSEF.

PY - 2005/12/16

Y1 - 2005/12/16

N2 - Ribosomal proteins not only act as components of the translation apparatus but also regulate cell proliferation and apoptosis. A previous study reported that MRPL41 plays an important role in p53-dependent apoptosis. It also showed that MRPL41 arrests the cell cycle by stabilizing p27Kip1 in the absence of p53. This study found that MRPL41 mediates the p21 WAF1/CIP1-mediated G1 arrest in response to serum starvation. The cells were released from serum starvation-induced G1 arrest via the siRNA-mediated blocking of MRPL41 expression. Overall, these results suggest that MRPL41 arrests the cell cycle by increasing the p21WAF1/CIP1 and p27Kip1 levels under the growth inhibitory conditions.

AB - Ribosomal proteins not only act as components of the translation apparatus but also regulate cell proliferation and apoptosis. A previous study reported that MRPL41 plays an important role in p53-dependent apoptosis. It also showed that MRPL41 arrests the cell cycle by stabilizing p27Kip1 in the absence of p53. This study found that MRPL41 mediates the p21 WAF1/CIP1-mediated G1 arrest in response to serum starvation. The cells were released from serum starvation-induced G1 arrest via the siRNA-mediated blocking of MRPL41 expression. Overall, these results suggest that MRPL41 arrests the cell cycle by increasing the p21WAF1/CIP1 and p27Kip1 levels under the growth inhibitory conditions.

KW - Cell cycle

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KW - Serum starvation

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KW - p27

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