Mixotrophic biorefinery: A promising algal platform for sustainable biofuels and high value coproducts

Anil Kumar Patel, Reeta Rani Singhania, Cheng Di Dong, Parthiba Karthikeyan Obulisami, Sang Jun Sim

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)


Mixotrophic microalgae cultivation is becoming the most promising and sustainable process for sustainable biosynthesis of biochemicals and biofuels. It offers significantly higher productivity to cope up the key challenges to develop industrial algal processes. Mixotrophic cultivation strategy (MCS) leads to better productivity due to the unique metabolic capacity of microalgae by combining both photosynthesis and oxidative metabolic pathways for biomass generation. The capacity of the mixotrophic phenomenon is being investigated for sustainable bioprocess development ensuring higher energy recovery, economy, environmental and social benefits. However, developments are in pipeline and still to attain a commercial phase. In this article, recent technological developments in MC bioprocess for biofuels production are discussed; synergistic carbon and energy regulation, critical discussion up on commercially important organic carbon sources and their effects on MC bioprocessing have been demonstrated; Moreover, the prospective and challenges of higher-scale MC-linked bioprocessing and future direction on technology development have been addressed.

Original languageEnglish
Article number111669
JournalRenewable and Sustainable Energy Reviews
Publication statusPublished - 2021 Dec

Bibliographical note

Publisher Copyright:
© 2021 Elsevier Ltd


  • Bioproducts
  • MCS
  • Microalgae
  • Mixotrophic
  • Organic carbon
  • Photosynthesis

ASJC Scopus subject areas

  • Renewable Energy, Sustainability and the Environment


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