MK-801, a non-competitive NMDA receptor antagonist, prevents postischemic decrease of inositol 1,4,5-trisphosphate receptor mRNA expression in mongolian gerbil brain

Chang Sub Uhm; Young Suk Suh; Joo Bae Park; Moon Bang Sohn; Im Joo Rhyu; Hyun Kim

doi:10.1016/S0304-3940(98)00727-7

MK-801, a non-competitive NMDA receptor antagonist, prevents postischemic decrease of inositol 1,4,5-trisphosphate receptor mRNA expression in mongolian gerbil brain

Chang Sub Uhm, Young Suk Suh, Joo Bae Park, Moon Bang Sohn, Im Joo Rhyu, Hyun Kim

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Changes of inositol 1,4,5-trisphosphate receptor (IP₃R) mRNA expression after transient brain ischemia and the effect of MK-801, a non-competitive N- methyl-D-aspartic acid (NMDA) receptor antagonist, on the IP₃R mRNA expression was studied in mongolian gerbil brain by in situ hybridization. Transient ischemia was induced by ligating left common carotid artery for 10 min, and the animals were allowed recovery from 15 min to 24 h. MK-801 was introduced intraperitoneally 30 min before ischemia. IP₃R mRNA expression was decreased in dentate gyrus and hippocampus from 90 min until 24 h after ischemia. MK-801 pretreatment prevented the change of IP₃R mRNA expression after ischemia. These results suggest that IP₃R mRNA expression in ischemia may be related with NMDA receptor.

Original language	English
Pages (from-to)	111-114
Number of pages	4
Journal	Neuroscience Letters
Volume	255
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3940(98)00727-7
Publication status	Published - 1998 Sept 2

Bibliographical note

Funding Information:
This work was supported in part by a Grant for Promoting Basic Medical Sciences of the Ministry of Education of Korea to C.-S.U.

Keywords

IP receptor
In situ hybridization
Ischemia
MK-801
Mongolian gerbil
N- Methyl-D-aspartic acid receptor

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/S0304-3940(98)00727-7

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title = "MK-801, a non-competitive NMDA receptor antagonist, prevents postischemic decrease of inositol 1,4,5-trisphosphate receptor mRNA expression in mongolian gerbil brain",

abstract = "Changes of inositol 1,4,5-trisphosphate receptor (IP3R) mRNA expression after transient brain ischemia and the effect of MK-801, a non-competitive N- methyl-D-aspartic acid (NMDA) receptor antagonist, on the IP3R mRNA expression was studied in mongolian gerbil brain by in situ hybridization. Transient ischemia was induced by ligating left common carotid artery for 10 min, and the animals were allowed recovery from 15 min to 24 h. MK-801 was introduced intraperitoneally 30 min before ischemia. IP3R mRNA expression was decreased in dentate gyrus and hippocampus from 90 min until 24 h after ischemia. MK-801 pretreatment prevented the change of IP3R mRNA expression after ischemia. These results suggest that IP3R mRNA expression in ischemia may be related with NMDA receptor.",

keywords = "IP receptor, In situ hybridization, Ischemia, MK-801, Mongolian gerbil, N- Methyl-D-aspartic acid receptor",

author = "Uhm, {Chang Sub} and Suh, {Young Suk} and Park, {Joo Bae} and Sohn, {Moon Bang} and Rhyu, {Im Joo} and Hyun Kim",

note = "Funding Information: This work was supported in part by a Grant for Promoting Basic Medical Sciences of the Ministry of Education of Korea to C.-S.U.",

year = "1998",

month = sep,

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doi = "10.1016/S0304-3940(98)00727-7",

language = "English",

volume = "255",

pages = "111--114",

journal = "Neuroscience Letters",

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T1 - MK-801, a non-competitive NMDA receptor antagonist, prevents postischemic decrease of inositol 1,4,5-trisphosphate receptor mRNA expression in mongolian gerbil brain

AU - Uhm, Chang Sub

AU - Suh, Young Suk

AU - Park, Joo Bae

AU - Sohn, Moon Bang

AU - Rhyu, Im Joo

AU - Kim, Hyun

N1 - Funding Information: This work was supported in part by a Grant for Promoting Basic Medical Sciences of the Ministry of Education of Korea to C.-S.U.

PY - 1998/9/2

Y1 - 1998/9/2

N2 - Changes of inositol 1,4,5-trisphosphate receptor (IP3R) mRNA expression after transient brain ischemia and the effect of MK-801, a non-competitive N- methyl-D-aspartic acid (NMDA) receptor antagonist, on the IP3R mRNA expression was studied in mongolian gerbil brain by in situ hybridization. Transient ischemia was induced by ligating left common carotid artery for 10 min, and the animals were allowed recovery from 15 min to 24 h. MK-801 was introduced intraperitoneally 30 min before ischemia. IP3R mRNA expression was decreased in dentate gyrus and hippocampus from 90 min until 24 h after ischemia. MK-801 pretreatment prevented the change of IP3R mRNA expression after ischemia. These results suggest that IP3R mRNA expression in ischemia may be related with NMDA receptor.

AB - Changes of inositol 1,4,5-trisphosphate receptor (IP3R) mRNA expression after transient brain ischemia and the effect of MK-801, a non-competitive N- methyl-D-aspartic acid (NMDA) receptor antagonist, on the IP3R mRNA expression was studied in mongolian gerbil brain by in situ hybridization. Transient ischemia was induced by ligating left common carotid artery for 10 min, and the animals were allowed recovery from 15 min to 24 h. MK-801 was introduced intraperitoneally 30 min before ischemia. IP3R mRNA expression was decreased in dentate gyrus and hippocampus from 90 min until 24 h after ischemia. MK-801 pretreatment prevented the change of IP3R mRNA expression after ischemia. These results suggest that IP3R mRNA expression in ischemia may be related with NMDA receptor.

KW - IP receptor

KW - In situ hybridization

KW - Ischemia

KW - MK-801

KW - Mongolian gerbil

KW - N- Methyl-D-aspartic acid receptor

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ER -

MK-801, a non-competitive NMDA receptor antagonist, prevents postischemic decrease of inositol 1,4,5-trisphosphate receptor mRNA expression in mongolian gerbil brain

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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