Model development for prediction of the allergic response to the wheat proteins ω-5 gliadin and HMW-glutenin

Yong Hoon Joo, Do Hun Lee, Nam Taek Lee, Namhyun Chung

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


As one of the eight foods that account for 90 % of food allergies, wheat must be excluded from the diet in patients suffering from wheat allergies. From studies of wheat-dependent exercise-induced anaphylaxis (WDEIA), which has been used as a model to develop hypoallergenic wheat, we now know that the gluten fraction of wheat protein, particularly ω-5 gliadin and high-molecular-weight (HMW)-glutenin, is responsible for the allergic response. However, studies of allergic responses with WDEIA have been performed with a single wheat cultivar. Thus, in an effort to provide more information for the development of hypoallergenic wheat, we compared various cultivars with different countries of origin and characteristics. For the first step, we compared the allergen contents (ω-5 gliadin and HMW-glutenin) in each cultivar and the allergic response caused by each cultivar. Domestic wheat cultivars had lower contents of ω-5 gliadin and HMW-glutenin than those of imported wheat cultivars. Additionally, some cultivars caused varying allergic responses due to their allergen components. From regression analysis of allergen contents and allergic responses in vivo, we suggest a prediction model to estimate the extent of allergic response based on the ω-5 gliadin and HMW-glutenin contents. Further studies are needed to analyze the biological interactions between allergens from various cultivars and allergic response factors.

Original languageEnglish
Pages (from-to)827-831
Number of pages5
JournalApplied Biological Chemistry
Issue number6
Publication statusPublished - 2016 Dec 1

Bibliographical note

Publisher Copyright:
© 2016, The Korean Society for Applied Biological Chemistry.


  • High-molecular-weight glutenin
  • Prediction model
  • Wheat allergy
  • Wheat-dependent exercise-induced anaphylaxis
  • ω-5 Gliadin

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology
  • Organic Chemistry


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