Abstract
A thermal microsystem is developed which consists of a microreactor integrated with a platinum sensor/heater, and automation equipment/software such as data acquisition system, control program and graphic user interface. From the control point of view, we analyze the dynamic characteristics of the fabricated microreactor and find some interesting dynamic features. On the basis of the analysis, we suggest an appropriate model structure and estimate the model parameters using the prediction error identification method. Requirements for a high-performance operation are discussed and a nonlinear control strategy is proposed to linearize the nonlinear dynamics of the thermal microsystem. We determine the parameters of the nonlinear controller using the optimal tuning method. The developed thermal microsystem shows much better control performances compared to commercial polymerase chain reaction (PCR) thermal cyclers. We successfully demonstrate the PCR of plasmid DNA using the thermal microsystem.
| Original language | English |
|---|---|
| Pages (from-to) | 105-111 |
| Number of pages | 7 |
| Journal | IFAC Proceedings Volumes (IFAC-PapersOnline) |
| Volume | 37 |
| Issue number | 1 |
| Publication status | Published - 2004 |
| Externally published | Yes |
| Event | 7th International Symposium on Advanced Control of Chemical Processes, ADCHEM 2003 - , Hong Kong Duration: 2004 Jan 11 → 2004 Jan 14 |
Bibliographical note
Funding Information:This work is supported by the BK21 Project and Center for Ultramicrochemical Process Systems sponsored by KOSEF.
Publisher Copyright:
Copyright © IFAC 2003
Keywords
- Nonlinear Control
- PID Controller
- Polymerase Chain Reaction
- System Identification
- Thermal Microsystems
ASJC Scopus subject areas
- Control and Systems Engineering