Modest weight loss does not increase plasma adiponectin levels: effects of weight loss on C-reactive protein and DNA damage

Min Jeong Shin, Oh Yoen Kim, Soo Jeong Koh, Jey Sook Chae, Ji Young Kim, Yangsoo Jang, Jong Ho Lee

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Adiponectin has been reported to have antiatherogenic, antidiabetic properties and was proposed as an important mediator of insulin action and glucose metabolism. This study was conducted to determine weight loss effects on the plasma adiponectin levels and clinical parameters including oxidative DNA damage and C-reactive protein (CRP) in overweight-obese subjects. A total of 184 overweight-obese volunteers underwent a clinical intervention study consisting of -1255 kJ/d for 12 weeks. Anthropometic parameters, blood lipid profiles, glucose, insulin, CRP, and baseline DNA damage using comet assay and adiponectin concentrations were determined at baseline and at 12 weeks of intervention. The treatment induced modest weight loss averaged 4.75% of initial body weight. C-reactive protein (P < .005); baseline DNA damages as measured by tail length (micrometers, P < .05), tail DNA (percentage, P < .001), and tail moment on DNA (P < .001); and the insulin resistance-related variables (P < .01 for glucose; P < .05 for homeostasis model assessment of insulin resistance) showed significant changes toward clinical improvement at the end of the intervention. However, no significant changes in plasma adiponectin levels were found after 12 weeks. When subjects were divided into 3 groups according to the degree of weight change, significant increases in plasma adiponectin levels were found only in the subjects with the greatest weight change. In conclusion, modest weight loss improved metabolic parameters including blood lipids, insulin resistance, CRP, and DNA damage, but did not increase plasma levels of adiponectin in overweight-obese subjects. However, the increases in plasma adiponectin after 12 weeks were observed in the subjects with a higher degree of weight loss.

Original languageEnglish
Pages (from-to)391-396
Number of pages6
JournalNutrition Research
Issue number8
Publication statusPublished - 2006 Aug
Externally publishedYes

Bibliographical note

Funding Information:
This study was supported by grants from the National Research Laboratory project, Ministry of Science and Technology, Kwachon, Korea (2005-01572), and the Korea Science and Engineering Foundation, Daejeon, Korea (R01-2003-0000-11709-0).


  • Adiponectin
  • C-reactive protein
  • DNA damage
  • Obese subjects
  • Weight loss

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics


Dive into the research topics of 'Modest weight loss does not increase plasma adiponectin levels: effects of weight loss on C-reactive protein and DNA damage'. Together they form a unique fingerprint.

Cite this